Bookshelf

125I-Single-chain antibody B1 targeting a pancreatic β-cell surface antigen (Added 05-21-2012)

2-chloro-N-((S)-((S)-1-[11C]methylpiperidine-2-yl)(thiophen-3-yl)methyl)-3-(trifluoromethyl)benzamide ([11C]SA1) and derivatives (Added 05-14-2012)

Polyethylene glycol-Cys-Arg-Ser-Gly-Pro-Leu-Gly-Val-Tyr-[18F]fluorobenzoyl-Lys-Lys-tetramethylrhodamine (Added 05-14-2012)

64Cu-Labeled NOTA-conjugated anti-CD105 (endoglin) chimeric monoclonal antibody linked to near-infrared dye IRDye 800CW (Added 05-14-2012)

111In-CHX-A”-Rhenium-cyclized-[Cys3,4,10,D-Phe7,Arg11]α-MSH3-13 (Added 05-14-2012)

N'-Fluorescein-N''-[4-O-(β-d-glucopyranuronic acid)-3-difluoromethylphenyl]-S-methylthiourea (FITC-TrapG) and N'-(p-aminophenyl)thioether of IR-820-N''-[4-O-(β-d-glucopyranuronic acid)-3-difluoromethylphenyl]-S-methylthiourea (NIR-TrapG) (Added 05-14-2012)

Polyethylene glycol-Cys-Arg-Ser-Gly-Pro-Leu-Gly-Val-Tyr-Lys-Lys-tetramethylrhodamine (Added 05-14-2012)

Cy5.5-Conjugated glycol chitosan-5β-cholanic acid nanoparticles (Added 05-14-2012)

Cy5.5-Cyclo(CGNSNPKSC) (Added 05-07-2012)

64Cu-1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid-cyclo(CGNSNPKSC) (Added 05-07-2012)

N1,N1-diethyl-N4-(7-[125I]iodoquinolin-4-yl)pentane-1,4-diamine (Added 05-07-2012)

Quinolinium, 1,1'-[1,3-propanediylbis[(dimethyliminio)-3,1-propanediyl]]bis[4-[3-(3-methyl-2(3H)-benzothiazolylidene)-1-propen-1-yl]-,iodide (1:4) (Added 05-07-2012)

1-O-(4-(2-[18F]Fluoroethyl-carbamoyloxymethyl)-2-nitrophenyl)-O-β-d-glucopyronuronate (Added 04-30-2012)

Methyl ester of 1-O-(4-(2-[18F]fluoroethyl-carbamoyloxymethyl)-2-nitrophenyl)-O-β-d-glucopyronuronate (Added 04-30-2012)

68Ga-1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid-aminohexanoic acid-Lys40-exendin-4 (Added 04-30-2012)

Tri-methoxy-tris-pyrazolyl-99mTc-(CO)3 (Added 04-30-2012)

99mTc-Labeled acetylated, 2,3,5-triiodobenzoic acid- and diethylenetriamine pentaacetic acid-conjugated, and PEGylated ethylenediamine-core generation 4 polyamidoamine dendrimers (Added 04-30-2012)

[11C]-[N-Methyl]3-[(3-fluorophenyl)sulfonyl]-8-(4-methyl-1-piperazinyl)quinoline (Added 04-30-2012)

99mTc-Hydrazinonicotinamide-aminohexanoic acid-Lys40-exendin-4 (Added 04-30-2012)

111In-Diethylenetriamine pentaacetic acid-anti-epithelial glycoprotein-1 hRS7 humanized monoclonal antibody (Added 04-23-2012)

11C-Labeled GSK931145 (Added 04-23-2012)

89Zr-Desferrioxamine-anti-epithelial glycoprotein-1 hRS7 humanized monoclonal antibody (Added 04-23-2012)

99mTc-Fucoidan, a polysaccharidic ligand of P-selectin (Added 04-16-2012)

99mTc-Labeled, PEGylated (NαHis)Ac-β3hLys-βAla-βAla-Gln7-Trp8-Ala9-Val10-Gly11-His12-Cha13-Nle14-NH2 (Added 04-16-2012)

Cy5.5-Containing matrix metalloproteinase (MMP) activatable peptide conjugated to glycol chitosan (GC)–coated gold nanoparticles (AuNPs) (Added 04-16-2012)

99mTcO-N,N-Dimethylglycyl-l-lysinyl-l-cysteinylamide-8-amino-3,6-dioxaoctanoic-probestin (Added 04-16-2012)

Cy5.5-Conjugated matrix metalloproteinase cleavable peptide nanoprobe (Added 04-16-2012)

1-(2'-Deoxy-2'-[18F]fluoro-β-d-arabinofuranosyl)-5-iodocytosine (Added 04-16-2012)

Cy5.5-Asp-Gly-Glu-Ala-Gly-Lys-(Arg)8-OH (Added 04-09-2012)

Cy5.5-Asp-Gly-Glu-Ala (DGEA) (Added 04-09-2012)

Alexa 680 conjugated to bovine serum albumin (Added 04-02-2012)

18F-Fluoroethyl triazole-βAG-[(d)-Phe1-c(Cys2-Tyr3-(d)-Trp4-Lys5-Thr6-Cys7)Thr8] (Added 04-02-2012)

111In-1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid-anti-insulin-like growth factor 1 receptor Affibody ZIGF1R:4551 (Added 04-02-2012)

N-2-(4-[18F]-Fluorobenzamido)ethylmaleimide coupled to cysteine-tagged epidermal growth factor (Added 04-02-2012)

18F-1,4,7-Triazacyclononane-1,4,7-triacetic acid-10-maleimidoethylacetamide-Affibody ZHER2:2395 (Added 04-02-2012)

N-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)-4-[18F]-fluorobenzamide ([18F]FBEM) conjugated to EM3106B, an analog of glucagon-like peptide-1 (Added 03-26-2012)

N-2-(4-[18F]-Fluorobenzamido)ethylmaleimide coupled to cysteine-tagged on the C- or N-terminal of exendin-4 (Added 03-26-2012)

111In-Labeled 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetracetic acid-Glu{PEG4-Glu[cyclo(Lys-Arg-Gly-Asp-d-Phe)]-cyclo(Lys-Arg-Gly-Asp-d-Phe)}-{PEG4-Glu[cyclo(Lys-Arg-Gly-Asp-d-Phe)]-cyclo(Lys-Arg-Gly-Asp-d-Phe)} (PEG4 = 15 amino-4,710,13-tetraoxapentadecanoic acid) (Added 03-26-2012)

111In-Labeled 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetracetic acid-Glu{PEG4-Glu[cyclo(Lys(Gly-Gly-Gly)-Arg-Gly-Asp-d-Phe)]-cyclo(Lys(Gly-Gly-Gly)-Arg-Gly-Asp-d-Phe)}-{PEG4-Glu[cyclo(Lys(Gly-Gly-Gly)-Arg-Gly-Asp-d-Phe)]-cyclo(Lys(Gly-Gly-Gly)-Arg-Gly-Asp-d-Phe)} (PEG4 = 15 amino-4,7,10,13-tetraoxapentadecanoic acid) (Added 03-26-2012)

1-Deoxy-1-[18F]fluoro-scyllo-inositol (Added 03-26-2012)

111In-Labeled 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetracetic acid-Glu{PEG4-Glu[cyclo(Lys(PEG4)-Arg-Gly-Asp-d-Phe)]-cyclo(Lys(PEG4)-Arg-Gly-Asp-d-Phe)}-{PEG4-Glu[cyclo(Lys(PEG4)-Arg-Gly-Asp-d-Phe)]-cyclo(Lys(PEG4)-Arg-Gly-Asp-d-Phe)} (PEG4 = 15 amino-4,7,10,13-tetraoxapentadecanoic acid) (Added 03-26-2012)

L-[5-11C]-Glutamine (Added 03-26-2012)

64Cu-Labeled 1,4,7-tris(acetic acid)-10-vinylsulfone-1,4,7,10-tetraazacyclododecane conjugated to Cys40-Exendin-4 (Added 03-19-2012)

18F-Labeled N-succinimidyl-4-fluorobenzoate–conjugated rat anti-mouse vascular endothelial growth factor receptor 2 monoclonal antibody linked to microbubbles (Added 03-19-2012)

64Cu-Z-E-(1,8-Diamino-3,6,10,13,16,19-hexaazabicyclo(6,6,6)eicosane)-aminohexanoyl-Asp-Gly-Glu-Ala (Added 03-19-2012)

64Cu-1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid-Asp-Gly-Glu-Ala (Added 03-19-2012)

18F-Labeled 5-(5-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N,N-dimethylpyridin-2-amine (Added 03-12-2012)

IRDye800CW-Cyclic albumin-binding domain (Ac-RLIEDICLPRWGCLWEDDK-NH2) (Added 03-05-2012)

Quenched indocyanine green-anti-prostate-specific membrane antigen antibody J591 (Added 03-05-2012)

18F-Labeled 4-(5-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N,N-dimethylbenzenamine (Added 03-05-2012)

64Cu-Labeled Lys40(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid)NH2–conjugated exendin-4 (Added 02-27-2012)

IRDye800CW-anti-CD105 TRC105 chimeric monoclonal antibody (Added 02-27-2012)

89Zr-Desferrioxamine B-7E11 anti-prostate-specific membrane antigen monoclonal antibody (Added 02-27-2012)

Pyridine-tetra-acetate-gadolinium(III) (PTA-Gd) conjugated to 17β-estradiol (EPTA-Gd) or tamoxifen (TPTA-Gd) (Added 02-27-2012)

Recombinant human erythropoietin coupled to near-infrared fluorescence dye Cy5.5 (Added 02-27-2012)

Obsessive-compulsive disorder: Can psychotherapy help? (Added 04-30-2012)

Expressing breast milk: Are some methods better than others? (Added 04-30-2012)

Obsessive-compulsive disorder does not have to rule your life (Added 04-30-2012)

Arthritis: What can prevent stomach ulcers caused by painkillers and who needs such protection? (Added 04-30-2012)

Fact sheet: Ticks (Added 04-30-2012)

The defense mechanisms of the adaptive immune system: An alliance of antibodies, T cells and soluble proteins (Added 04-30-2012)

Premenstrual syndrome: Can relaxation techniques or psychological treatments relieve the symptoms? (Added 04-30-2012)

Gestational diabetes: Frequently asked questions (Added 04-30-2012)

Migraine diary (Added 04-30-2012)

How do the innate and adaptive immune systems work together? (Added 04-30-2012)

Removing ticks (Added 04-30-2012)

Diet and body weight: What is the effect of soft drinks and other beverages sweetened with sugar? (Added 03-28-2012)

Breast cancer: Does exercise improve quality of life? (Added 03-28-2012)

Fact sheet: Living with metastatic breast cancer (Added 03-28-2012)

Chronic hepatitis C: What are the advantages or disadvantages of boceprevir? (Added 03-28-2012)

Angina pectoris and heart attack: What are the advantages or disadvantages of ticagrelor? (Added 03-28-2012)

How does the nervous system work? (Added 03-28-2012)

Low back pain: Can exercise prevent recurrences? (Added 03-28-2012)

Fact sheet: Test for gestational diabetes (Added 03-28-2012)

Fact sheet: Saying goodbye (Added 03-28-2012)

Breast cancer: Can dairy products influence the risk? (Added 03-28-2012)

Advanced breast cancer: Is high-dose chemotherapy plus autologous blood stem cell transplantation an option? (Added 03-28-2012)

Fact sheet: Information for partners (Added 03-28-2012)

How does chemotherapy work? (Added 03-28-2012)

Soft tissue sarcoma: Does high-dose chemotherapy in combination with autologous blood stem cell transplantation have a benefit? (Added 03-28-2012)

How does the brain work? (Added 03-28-2012)

Low back pain: Warning signs of a serious cause (Added 03-28-2012)

Pelvic floor tips in everyday life (Added 03-01-2012)

Overactive bladder: What helps women who have the urge to urinate very frequently? (Added 03-01-2012)

How do I decide: How can Informed Health Online help? (Added 03-01-2012)

Diagnostics: Why doing more is not always better (Added 03-01-2012)

Bladder training (Added 03-01-2012)

How do I decide? (Added 03-01-2012)

How do I decide: Evaluating information (Added 03-01-2012)

How do I decide: Collecting information (Added 03-01-2012)

Systematic review and validation of prediction rules for identifying children with serious infections in emergency departments and urgent-access primary care. (Added 04-02-2012)

A systematic review of the clinical effectiveness and cost-effectiveness of Pharmalgen® for the treatment of bee and wasp venom allergy. (Added 04-02-2012)

EOS 2D/3D X-ray imaging system: a systematic review and economicevaluation (Added 04-02-2012)

CRASH-2 (Clinical Randomisation of an Antifibrinolytic in SignificantHaemorrhage) intracranial bleeding study: the effect of tranexamic acid in traumaticbrain injury, a nested randomised, placebo-controlled trial. (Added 04-02-2012)

A pragmatic randomised controlled trial to evaluate the cost-effectiveness of a physical activity intervention as a treatment for depression: the treating depression with physical activity (TREAD) trial. (Added 04-02-2012)

Non-invasive diagnostic assessment tools for the detection of liver fibrosis in patients with suspected alcohol-related liver disease: a systematic review and economic evaluation (Added 03-01-2012)

Verteporfin photodynamic therapy for neovascular age-related maculardegeneration: cohort study for the UK. (Added 03-01-2012)

What is the clinical effectiveness and cost-effectiveness of using drugs in treating obese patients in primary care? A systematic review. (Added 03-01-2012)

Group art therapy as an adjunctive treatment for people with schizophrenia: arandomised controlled trial (MATISSE). (Added 03-01-2012)

An evaluation of the feasibility, cost and value of information of a multicentrerandomised controlled trial of intravenous immunoglobulin for sepsis (severe sepsisand septic shock): incorporating a systematic review, meta-analysis and value ofinformation analysis (Added 03-01-2012)

A systematic review of prevention and intervention strategies for populations at high risk of engaging in violent behaviour: update 2002–8. (Added 03-01-2012)

Discovery of a Highly Selective in vitro and invivo M1 Allosteric Agonist Probe (Added 02-29-2012)

Antagonists of IAP-family anti-apoptotic proteins - Probe 1 (Added 02-29-2012)

Probe Report for NOX1 Inhibitors (Added 02-29-2012)

Placental Alkaline Phosphatase (PLAP) Luminescent HTS assay - Probe 1 (Added 02-29-2012)

A high-throughput screen for pre-mRNA splicing modulators (Added 02-29-2012)

Therapeutic Inhibitors of Phosphomannose Isomerase - Probe 1 (Added 02-29-2012)

Probe Report for P97/cdc48 Inhibitors (Added 02-29-2012)

Discovery of a Highly Selective KCC2 Antagonist (Added 02-29-2012)

High Throughput Screening for Small Molecule Inhibitors of Heparin-induced TauFibril Formation (Added 02-29-2012)

HTS for Identification of Inhibitors against the ERK Signaling Pathway using aHomogenous Cell-based Assay (Added 02-29-2012)

Therapeutic Inhibitors of Phosphomannose Isomerase - Probe 2 (Added 02-29-2012)

Placental Alkaline Phosphatase (PLAP) Luminescent HTS assay - Probe 2 (Added 02-29-2012)

Inhibitors of Protein Folding: DnaK (Added 02-29-2012)

Probe Report for NPY-Y2 Receptor Antagonists (Added 02-29-2012)

The Role of PHOSPHO1 in the Initiation of Skeletal Calcification (Added 02-29-2012)

uHTS for the identification of compounds that potentiate TRAIL-induced apoptosis of cancer cells (Added 02-29-2012)

High throughput screening for SMA (Added 02-29-2012)

Identification of Functionally Selective Small Molecule Antagonists of theNeuropeptide-S Receptor: Naphthopyranopyrimidines (Added 02-29-2012)

Three small molecule pan activator families of Ras-related GTPases (Added 02-29-2012)

High Throughput Screening Assays for NOD1 Inhibitors - Probe 1 (Added 02-29-2012)

Discovery of a potent, selective and in vivo active mGluR4 positive allosteric modulator (Added 02-29-2012)

Discovery of a small molecule inhibitor of ROMK and Kir7.1 (Added 02-29-2012)

Probe Report for PME-1 Inhibitors (Added 02-29-2012)

Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator (PAM) (Added 02-29-2012)

Selective KOP Receptor Antagonists: Probe 1 (Added 02-29-2012)

Probe Report for RBBP9 Inhibitors - Probe 2 (Added 02-29-2012)

Discovery of the first mAChR 5 (M5) selective ligand, an M5 Positive Allosteric Modulator (PAM) (Added 02-29-2012)

A potent and selective small molecule Kir2.1 inhibitor (Added 02-29-2012)

Small-Molecule Inhibitors of Vaccinia-H1-Related Phosphatase VHR (Added 02-29-2012)

Selective KOP Receptor Agonists: Probe 1 & Probe 2 (Added 02-29-2012)

Discovery and development of the a highly selective M1 Positive Allosteric Modulator (PAM) (Added 02-29-2012)

Selective HePTP Inhibitors: Probe 1 (Added 02-29-2012)

Selective HePTP Inhibitors: Probe 2 (Added 02-29-2012)

A Cell Based Assay for the Identification of Lead Compounds with Anti-Viral Activity Against West Nile Virus (Added 02-29-2012)

Discovery of a small molecule inhibitor of ROMK with unprecedented selectivity (Added 02-29-2012)

High Throughput Screening Assays for NOD1 Inhibitors - Probe 2 (Added 02-29-2012)

Selective GPR35 Antagonists - Probes 1 & 2 (Added 02-29-2012)

Discovery and development of a second highly selective M1 Positive Allosteric Modulator (PAM) (Added 02-29-2012)

Modulators of STAT Transcription Factors for the Targeted Therapy of Cancer (STAT3 Activators) (Added 02-29-2012)

A Potent and Selective Inhibitor of Cdc42 GTPase (Added 02-29-2012)

Identification of Small Molecule Antagonists of the Neuropeptide-SReceptor (Added 02-29-2012)

Probe Development Efforts to Identify Novel Antagonists of the Sphingosine 1-phosphate Receptor 4 (S1P4) (Added 02-29-2012)

Chemical Genetic Analysis of Platelet Granule Secretion-Probe 3 (Added 02-29-2012)

Chemical Genetic Analysis of Platelet Granule Secretion-Probe 1 (Added 02-29-2012)

Antagonists of IAP-family anti-apoptotic proteins - Probe 2 (Added 02-29-2012)

Identification of a small molecule that selectively inhibits alpha-synuclein translational expression (Added 02-29-2012)

Identification of Small-Molecule Inhibitors of Trypansoma cruzi Infection (Added 02-29-2012)

Identification of a small molecule that selectively activates alpha-synuclein translational expression (Added 02-29-2012)

Chemical Genetic Analysis of Platelet Granule Secretion-Probe 2 (Added 02-29-2012)

Identification of activators for the M2 isoform of human pyruvate kinase Version 3 (Added 02-29-2012)

Small Molecule Inhibitors of Wee1 Degradation and Mitotic Entry (Added 02-29-2012)

Identification of small molecules that selectively inhibit streptokinase expression without suppression of viability in Group A streptococci - Probe 2 (Added 02-29-2012)

Identification of small molecules that selectively inhibit streptokinase expression without suppression of viability in Group A streptococci - Probe 1 (Added 02-29-2012)

Identification of Modulators of the N370S Mutant Form of Glucocerebrosidase as a PotentialTherapy for Gaucher Disease - Chemotype 2 (Added 02-29-2012)

Inhibitors of Platelet Integrin αllbβ3 (Added 02-29-2012)

Identification of Small-Molecule Inhibitors of Trypansoma cruzi Infection - Probe 1 (Added 02-29-2012)

Modulators of STAT Transcription Factors for the Targeted Therapy of Cancer (STAT3 Inhibitors) (Added 02-29-2012)

Identification of compounds which inhibit cytotoxicity associated with mutant Huntingtin protein expression (Added 02-29-2012)

Identification of Potent and Selective Thyroid Stimulating Hormone Receptor Agonists (Added 02-29-2012)

Selective Small Molecule Inhibitors of 12-Human Lipoxygenase (12-hLO) (Added 02-29-2012)

An inhibitor of the Cdc2-like kinase 4 (Clk4) (Added 02-29-2012)

Toward Improved Therapy for Classic Galactosemia (Added 02-29-2012)

qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 (Added 02-29-2012)

Campaign to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR) (Added 02-29-2012)

Identification of small molecules that selectively inhibit streptokinaseexpression without suppression of viability in Group A streptococci - Probe3 (Added 02-29-2012)

A small molecule inhibitor of Caspase 1 (Added 02-29-2012)

Identification of Small-Molecule Inhibitors of Trypansoma cruzi Infection - Probe 3 (Added 02-29-2012)

Potent and selective inhibitors of NAD+-dependent15-hydroxyprostaglandin dehydrogenase (HPGD) (Added 02-29-2012)

Discovery, SAR and Biological Evaluation of Aryl-thiazol-piperidines as SMN Modulators (Added 02-29-2012)

HTS Assay for Discovery of Novel Metallo-Beta-lactamase (MBL) Inhibitors (Added 02-29-2012)

Identification of Inhibitors of Trypanosoma brucei Hexokinases (Added 02-29-2012)

Identification of Modulators of the N370S Mutant Form of Glucocerebrosidase as a PotentialTherapy for Gaucher Disease - Chemotype 1 (Added 02-29-2012)

Novel Chemical Inhibitor of TRPC4 Channels (Added 02-29-2012)

Identification of Small Molecule Inhibitors that Suppress Cytokine-Induced Apoptosis in Human Pancreatic Islet Cells (Added 02-29-2012)

Campaign to Identify Agonists of Transient Receptor Potential Channels 3 and 2 (TRPML3 & TRPML2) (Added 02-29-2012)

Antagonist for the Kappa Opioid Receptor (Added 02-29-2012)

Screening for Selective Ligands for GPR55 - Agonists (Added 02-29-2012)

Screening for Selective Ligands for GPR55 - Antagonists (Added 02-29-2012)