Table A14.7NMA results for Stroke or Systemic Embolism stratified by CHADS2 score

CHADS2< 2
Standard
Adjusted-Dose
Warfarin		Apixaban 5 mg
b.i.d.		Dabigatran 110
mg b.i.d.		Dabigatran 150
mg b.i.d.		No
treatment/Placebo		LDASAMDASA
Apixaban 5 mg b.i.d.0.86(0.57,1.28)
Dabigatran 110 mg b.i.d.1(0.64,1.55)1.17(0.64,2.13)
Dabigatran 150 mg b.i.d.0.61(0.37,1)0.71(0.37,1.36)0.61(0.37,0.996)
No treatment/Placebo1.88(0.69,5.74)2.21(0.74,7.29)1.89(0.62,6.26)3.11(1.01,10.5)
LDASA2.2(1.18,4.25)2.57(1.22,5.6)2.21(1.03,4.87)3.62(1.62,8.29)1.17(0.33,3.91)
MDASA1.97(0.63,6.73)2.31(0.69,8.45)1.98(0.59,7.3)3.25(0.94,12.12)1.05(0.62,1.77)0.9(0.24,3.53)
Clopidogrel 75 mg OD & LDASA3.16(1.39,8.22)3.71(1.48,10.4)3.18(1.24,9.05)5.22(1.98,15.2)1.69(0.42,6.77)1.44(0.5,4.47)1.61(0.36,7.07)
CHADS2≥ 2
Standard Adjusted-
Dose Warfarin		Apixaban 5 mg b.i.d.Dabigatran 110 mg
b.i.d.		Dabigatran 150 mg
b.i.d.		Rivaroxaban 20 mg
OD		LDASA
Apixaban 5 mg b.i.d.0.78(0.63,0.95)
Dabigatran 110 mg b.i.d.0.89(0.71,1.12)1.15(0.84,1.57)
Dabigatran 150 mg b.i.d.0.66(0.52,0.85)0.86(0.62,1.18)0.75(0.58,0.96)
Rivaroxaban 20 mg OD0.88(0.74,1.04)1.13(0.87,1.47)0.98(0.74,1.31)1.32(0.98,1.78)
Low-dose ASA2.1(0.91,5.15)2.71(1.15,6.8)2.37(1,5.95)3.17(1.33,7.99)2.4(1.03,5.98)
Clopidogrel 75 mg OD & Low-dose ASA1.8(1.29,2.52)2.32(1.57,3.44)2.02(1.35,3.04)2.7(1.79,4.12)2.05(1.42,3)0.85(0.33,2.09)

From: APPENDIX 14, PAIRWISE COMPARISONS FROM NETWORK META-ANALYSIS

Cover of Antithrombotic Agents for the Prevention of Stroke and Systemic Embolism in Patients With Atrial Fibrillation
Antithrombotic Agents for the Prevention of Stroke and Systemic Embolism in Patients With Atrial Fibrillation [Internet].
CADTH Therapeutic Review, No. 1.1B.
Copyright © CADTH February 2013.

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