This eighth edition of the Guide for the Care and Use of Laboratory Animals has been reviewed in draft form by individuals chosen for their diverse perspectives and expertise, in accordance with procedures approved by the Report Review Committee of the National Research Council. The purpose of this independent review is to provide candid and critical comments that will assist the Committee in making its published report as sound as possible, and to ensure that the report meets institutional standards for objectivity, evidence, and responsiveness to the study charge. The review comments and draft manuscript remain confidential to protect the integrity of the deliberation process. The Committee thanks the following individuals for their review of the draft report:

Michael B. Ballinger, Amgen

Philippe J.R. Baneux, PreLabs

Stephen W. Barthold, University of California-Davis

Linda C. Cork, Stanford University

Jann Hau, University of Copenhagen, Denmark

Michael J. Huerkamp, Emory University

Michael D. Kastello, sanofi-aventis

Arthur L. Lage, Harvard Medical School

Christian Lawrence, Children’s Hospital Boston

Randall J. Nelson, University of Tennessee College of Medicine-Memphis

Steven M. Niemi, Massachusetts General Hospital

Melinda A. Novak, University of Massachusetts-Amherst

Gemma Perretta, National Research Council, Italy

Marky E. Pitts, IACUC Consultant

George E. Sanders, University of Washington

Allen W. Singer, Battelle Memorial Institute

William J. White, Charles River Laboratories

Although the reviewers listed above have provided many constructive comments and suggestions, they were not asked to endorse the conclusions or recommendations nor did they see the final draft of the report before its release. The review of this report was overseen by John Dowling, Harvard University, and John Vandenbergh, North Carolina State University. Appointed by the National Research Council, they were responsible for making certain that an independent examination of this report was carried out in accordance with institutional procedures and that all review comments were carefully considered. Responsibility for the final content of this report rests entirely with the authoring committee and the institution.