NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Bast RC Jr, Kufe DW, Pollock RE, et al., editors. Holland-Frei Cancer Medicine. 5th edition. Hamilton (ON): BC Decker; 2000.
Table 9.4Angiogenesis Inhibitors in Clinical Trials
| Phase I | ||
|---|---|---|
| Drug | Sponsor | Mechanism |
| COL-3 | Collagenex, NCI | Synthetic MMP inhibitor; tetracycline derivative |
| Combretastatin | Oxigene | apoptosis in Prolliferating endothelium |
| BMS-275291 | Bristol-Myers Squibb | Syhthetic MMP Inhibitor |
| SU668 | Sugen | Blocks VEGF, FGF & EGF receptor signaling |
| Endostatin | EntreMed | Inhibits endothelial proliferation |
| Phase II | ||
| Squalamine | Magainin | Inhibits Na/H exhanger |
| PTK787/ZK22584 | Novartis | Blocks VEGF receptor signaling |
| TNP-470 | TAP Pharm. | Fumagillin analogue; inhibits endothelial proliferation |
| Thalidomide | Celgene | Unknown |
| SU5416 | Sugen | Blocks VEFG receptor signaling |
| Vitaxin | Ixsys | Antibody to integrin on endothelial surface |
| Interleukin-12 | Genetics Inst. | Induces IFN-gamma and IP-10 |
| CAI | NCI | Inhibits calcium influx |
| Anti-VEGF Ab | Genentech | Monoclonal antibody to VEFG |
| Phase III | ||
| Marimastat | British Biotech | Synthetic MMP inhibitor |
| AG3340 | Agouron | Synthetic MMP Inhibitor |
| Neovastat | Aetema | Natural MMP inhibitor |
| Interferon-alfa | Commercially available | Inhibition of bFGF production |
| IM862 | Cytran | Endothelial inhibitor |
From National Cancer Institute Database (Updated November 23, 1999).
- Table 9.4, Angiogenesis Inhibitors in Clinical Trials - Holland-Frei Cancer Medi...Table 9.4, Angiogenesis Inhibitors in Clinical Trials - Holland-Frei Cancer Medicine
Your browsing activity is empty.
Activity recording is turned off.
See more...