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Gilbert SF. Developmental Biology. 6th edition. Sunderland (MA): Sinauer Associates; 2000.

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Cover of Developmental Biology

Developmental Biology. 6th edition.

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Figure 17.9. Phenotypic sex reversal in humans having two copies of the DAX1 locus.

Figure 17.9

Phenotypic sex reversal in humans having two copies of the DAX1 locus. DAX1 (on the X chromosome) plus SRY (on the Y chromosome) produces testes. DAX1 without SRY (since the other DAX1 locus is on the inactive X chromosome) produces ovaries. Two active copies of DAX1 (on the active X chromosome) plus SRY (on the Y chromosome) lead to a poorly formed gonad. Since the gonad makes neither AMH nor testosterone, the phenotype is female. (After Genetics Review Group 1995.)

From: Chromosomal Sex Determination in Mammals

Copyright © 2000, Sinauer Associates.

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