Figure 11.7. Actin-bundling proteins.

Figure 11.7Actin-bundling proteins

Actin filaments are associated into two types of bundles by different actin-bundling proteins. Fimbrin has two adjacent actin-binding domains (ABD) and crosslinks actin filaments into closely packed parallel bundles in which the filaments are approximately 14 nm apart. In contrast, the two separated actin-binding domains of α-actinin dimers crosslink filaments into more loosely spaced contractile bundles in which the filaments are separated by 40 nm. Both fimbrin and α-actinin contain two related Ca2+-binding domains, and α-actinin contains four repeated α-helical spacer domains.

From: Structure and Organization of Actin Filaments

Cover of The Cell
The Cell: A Molecular Approach. 2nd edition.
Cooper GM.
Sunderland (MA): Sinauer Associates; 2000.
Copyright © 2000, Geoffrey M Cooper.

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