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Grippo PJ, Munshi HG, editors. Pancreatic Cancer and Tumor Microenvironment. Trivandrum (India): Transworld Research Network; 2012.

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Pancreatic Cancer and Tumor Microenvironment.

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Editors: Paul Grippo, PhD and Hidayatullah G. Munshi, MD.

The Robert H. Lurie Comprehensive Cancer Center of Northwestern University Chicago, IL 60611, USA

Pancreatic cancer, one of the deadliest of human cancers, is associated with pronounced collagen-rich stromal reaction. This ‘desmoplastic reaction’ is being increasingly recognized as an active contributor to pancreatic cancer progression. There is significant interplay between the stroma and the cancer cells to induce epithelial-mesenchymal transition (EMT), modulate microRNAs, affect the number and function of both the cancer stem cells and the mesenchymal stem cells, and also contribute to chemo-resistance. As our understanding of the role and regulation of this desomplastic reaction increases, it may provide therapeutic targets against this deadly cancer.

The goal of this monograph is to review the importance of the stromal reaction in pancreatic cancer. Particular emphasis is placed on mesenchymal cells and how their propensity to modulate the tumor microenvironment results in tumor growth, invasion and metastasis. The various chapters address key pathways that modulate mesenchymal cells and how these pathways function to modulate EMT, stem cells and contribute to the generation of the stromal compartment. These effects are likely contributors to the aggressive nature of pancreatic cancer, ultimately responsible for poor prognosis and reduced survival. These chapters also identify potential therapeutic targets and summarize ongoing clinical trials designed to specifically target the stromal reaction present in pancreatic cancer. Thus, there is potential for enhanced efficacy with current chemotherapeutics, even those defined as ineffective as single agents in pancreatic cancer, if we can successfully target the stromal reaction.

We feel privileged to have worked on this monograph with an outstanding group of co-authors from throughout the world. Many of them have a long-term interest in understanding the biology of pancreatic cancer, including the involvement of the ECM, and continue to be leaders in this area of cancer research. As this monograph would not have been possible without their contributions, we owe them a debt of gratitude. The quality of this monograph reflects their hard work and is to their credit.

We are also grateful to Mrs. A. Gayathri, Publication Manager, and Dr. S.G. Pandalai, Managing Editor at Transworld Research Network Publishers, who have worked diligently to bring this monograph to publication. Their assistance is much appreciated.

Copyright © 2012, Transworld Research Network.
Bookshelf ID: NBK98935


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