Figure 6. Lack of glutathione reactivity of ML194.

Figure 6Lack of glutathione reactivity of ML194

(a) schematics of S9 incubation -ML194 was incubated with glutathione and rat S9 fraction for 1.5 hours. (b) HPLC-MS analysis showed 98.4% of the parent compound remained after 1.5 hours. Also, no GSH adduct masses were detected.

From: Selective GPR35 Antagonists - Probe 3

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Probe Reports from the NIH Molecular Libraries Program [Internet].

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