Figure 9. In Situ inhibition of PME-1 activity (A) and PME-1-mediated PP2A demethylation (B) by probe compound 1 (SID 99206500) and compound 3 (SID 99206503).

Figure 9In Situ inhibition of PME-1 activity (A) and PME-1-mediated PP2A demethylation (B) by probe compound 1 (SID 99206500) and compound 3 (SID 99206503)

A is a fluorescent image shown in grey scale; B is a Western blot chemiluminescent exposure; assay performed with cultured HeLa cells; bands corresponding to PME-1 and demethylated PP2A are indicated on the gel.

From: Probe Development Efforts to Identify Novel Inhibitors of Protein Phosphatase Methylesterase-1 (PME-1)

Cover of Probe Reports from the NIH Molecular Libraries Program
Probe Reports from the NIH Molecular Libraries Program [Internet].

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