Figure 15Structure of AI-1 Versus the Probe ML214

Chemically related compound AI-1 is active in an antioxidant response element (ARE) assay while the probe ML214, despite its apparently similar reactive functionality, is inactive in the ARE assay.

Probe CID 701939, ML214.

Probe CID 701939, ML214

Inactive as a ARE activator

Desired A1-selectivity profile

AI-1.

AI-1

ARE activator

From: Discovery of Inhibitors of Anti-Apoptotic Protein A1

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Probe Reports from the NIH Molecular Libraries Program [Internet].

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