Table 3Summary of accuracy data evaluating ECHO for diagnosing CAD

StudyPatient MixQualityPatients (N)Cath %Prevalence %Sensitivity %
(95% CI)
Specificity %
(95% CI)
PPV %
(95% CI)
NPV %
(95% CI)
LR+
(95% CI)
LR−
(95% CI)
Lu, et al., 201028No known CADGood76 (women)≥ 504187
(75–99)
82
(71–93)
77
(63–91)
90
(81–99)
4.90
(2.58–9.32)
0.16
(0.06–0.40)
Lewandowski, et al., 200741No known CADGood192 (women)≥ 503579
(70–89)
71
(63–79)
60
(50–70)
86
(80–93)
2.74
(2.03–3.70)
0.29
(0.18–0.47)
359 (men)7587
(82–91)
66
(55–76)
88
(84–92)
63
(53–73)
2.55
(1.91–3.41)
0.20
(0.14–0.28)
Lehmkuhl, et al., 200727No known CADGood114 (women)≥ 503980
(68–92)
81
(72–90)
73
(61–86)
86
(78–95)
4.25
(2.55–7.08)
0.25
(0.14–0.45)
Severi, et al., 199446No known CADGood122 (women)≥ 753468
(54–83)
96
(92–100)
90
(80–100)
86
(79–93)
18.44
(5.96–57.07)
0.33
(0.21–0.52)
307 (men)
6776
(70–82)
84
(76–91)
91
(86–95)
64
(56–72)
4.85
(3.07–7.66)
0.28
(0.22–0.37)
Sawada, et al., 198973No known CADGood57 (women)≥ 504986
(73–99)
86
(74–99)
86
(73–99)
86
(74–99)
6.21
(2.47–15.63)
0.17
(0.07–0.42)
Rollan, et al., 200254No known CADFair99 (women)≥ 504269
(55–83)
89
(82–97)
83
(70–95)
80
(70–90)
6.56
(3.00–14.36)
0.35
(0.22–0.55)
Williams, et al., 199474No known CADFair70 (women)≥ 504788
(77–99)
84
(72–96)
83
(70–95)
89
(78–99)
5.42
(2.58–11.40)
0.14
(0.06–0.37)
Marwick, et al., 199555No known CADFair161 (women)≥ 503780
(69–90)
81
(74–89)
71
(60–82)
87
(81–94)
4.28
(2.79–6.55)
0.25
(0.15–0.42)
Dionisopoulos, et al., 199775No known CADFair101 (women)≥ 506690
(82–97)
79
(66–93)
90
(82–97)
79
(66–93)
4.35
(2.24–8.46)
0.13
(0.06–0.27)
137 (men)7685
(78–91)
96
(85–99)
98
(96–100)
67
(56–79)
19.2
(4.94–74.44)
0.15
(0.10–0.23)
Mazeika, et al., 199276No known CADFair14 (women)≥ 705057
(20–94)
71
(38–100)
67
(29–100)
63
(29–96)
2.00
(0.53–7.60)
0.6
(0.23–1.60)
41 (men)8033
(18–52)
88
(47–1.00)
92
(76–100)
24
(9–40)
2.67
(0.40–17.76)
0.76
(0.53–1.09)
Slavich, et al., 199677No known CADFair49 (women)≥ 504559
(39–80)
75
(58–92)
68
(48–89)
67
(49–84)
2.36
(1.09–5.13)
0.55
(0.31–0.95)
Takeuchi, et al., 199678No known CADFair70 (women)≥ 502975
(56–94)
92
(84–100)
79
(61–97)
90
(82–98)
9.38
(3.54–24.82)
0.27
(0.13–0.58)
Masini, et al., 198861No known CADFair68 (women)≥ 703877
(61–93)
93
(85–100)
87
(73–100)
87
(77–97)
10.77
(3.55–32.70)
0.25
(0.12–0.50)
Roger, et al., 199779No known CADPoor96 (women)≥ 506079
(69–90)
37
(22–52)
66
(55–77)
54
(35–73)
1.26
(0.95–1.66)
0.56
(0.29–1.08)
244 (men)8078
(71–83)
44
(30–59)
84
(79–90)
34
(22–45)
1.39
(1.08–1.80)
0.50
(0.33–0.76)
Laurienzo, et al., 199739MixedGood84 (women)≥ 702682
(66–98)
100
(95–100)
100
(83–100)
94
(88–100)
NA0.18
(0.07–0.44)
Elhendy, et al., 199871MixedGood70 (women)≥ 506478
(66–90)
92
(81–100)
95
(87–100)
70
(54–85)
9.72
(2.55–37.07)
0.24
(0.14–0.42)
Lewis, et al., 199972MixedGood92 (women)≥ 502740
(21–59)
81
(71–90)
43
(23–64)
78
(69–88)
2.06
(1.04–4.09)
0.74
(0.53–1.05)
Shin, et al., 200369MixedFair162 (women)≥ 503482
(72–92)
71
(62–80)
59
(48–70)
88
(82–95)
2.82
(2.05–3.90)
0.26
(0.14–0.45)
302 (men)5579
(72–85)
80
(72–86)
83
(77–89)
76
(68–83)
3.95
(2.80–5.59)
0.26
(0.19–0.36)
Elhendy, et al., 199735MixedFair96 (women)≥ 506576
(65–86)
94
(86–100)
96
(90–100)
68
(55–81)
12.89
(3.33–49.80)
0.26
(0.16–0.40)
210 (men)8173
(66–80)
77
(61–89)
93
(89–98)
39
(28–50)
3.17
(1.77–5.66)
0.35
(0.26–0.47)
Bjornstad, et al., 199570MixedFair7 (women)≥ 508683
(54–100)
100
(NA-100)
100
(40–100)
50
(NA-100)
NA0.17
(0.03–1.00)
30 (men)9368
(48–84)
100
(55–1.00)
100
(84–100)
36
(11–61)
NA0.32
(0.19–0.55)
Agati, et al., 199256MixedFair10 (women)≥ 705080
(45–100)
100
(40–100)
100
(25–100)
83
(54–100)
NA0.20
(0.03–1.15)
22 (men)8695
(74–1.00)
100
(37–1.00)
100
(83–100)
75
(33–100)
NA0.05
(0.01–0.35)
Masini, et al., 198861MixedFair83 (women)≥ 7047
79
(67–92)
93
(86–100)
91
(82–100)
84
(73–94)
11.66
(3.87–35.16)
0.22
(0.12–0.41)
Ho, et al., 199867MixedFair51 (women)≥ 505793
(77–99)
82
(60–95)
87
(75–99)
90
(77–100)
5.12
(2.10–12.49)
0.08
(0.02–0.32)

Abbreviations: CAD = coronary artery disease; Cath % = % stenosis defined to be positive for CAD on diagnostic cardiac catheterization (coronary angiography); CI = confidence interval; LR+ = positive likelihood ratio; LR− = negative likelihood ratio; NPV = negative predictive value; NR = not reported; PPV = positive predictive value

From: Results

Cover of Noninvasive Technologies for the Diagnosis of Coronary Artery Disease in Women
Noninvasive Technologies for the Diagnosis of Coronary Artery Disease in Women [Internet].
Comparative Effectiveness Reviews, No. 58.
Dolor RJ, Patel MR, Melloni C, et al.

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