Figure 32 depicts thromboembolic events by rFVIIa dose per indication
for ICH, body trauma, brain trauma, liver transplantation, adult cardiac
surgery, pediatric cardiac surgery, and prostatectomy. There are seven mini
scatter graphs in this figure. At the left is a thromboembolic event rate
from 0.0 to 0.5, and at the bottom are rFVIIa Doses from 0 to 400. Data
points in this figure include only the intervention arms (i.e. rFVIIa
patients) from comparative studies. A data point for each dosing arm is
presented for RCTs with multiple dosing arms; thus, the number of studies
may not equal the number of data points. In general, there was no apparent
pattern relating age and thromboembolic events, although it is notable that
the ages tended to cluster for a given indication. There was also no
apparent pattern between dose and mortality or dose and thromboembolic
events (with the possible exception of brain trauma, which is discussed
separately.

Figure 32Thromboembolic events by rFVIIa dose per indication

Data points in this figure include only the intervention arms (i.e. rFVIIa patients) from comparative studies. A data point for each dosing arm is presented for RCTs with multiple dosing arms; thus, the number of studies may not equal the number of data points.

From: Results

Cover of Comparative Effectiveness of In-Hospital Use of Recombinant Factor VIIa for Off-Label Indications vs. Usual Care
Comparative Effectiveness of In-Hospital Use of Recombinant Factor VIIa for Off-Label Indications vs. Usual Care [Internet].
Comparative Effectiveness Reviews, No. 21.
Yank V, Tuohy CV, Logan AC, et al.

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