Figure 13.34. Ras activation downstream of receptor protein-tyrosine kinases.

Figure 13.34Ras activation downstream of receptor protein-tyrosine kinases

A complex of Grb2 and the guanine nucleotide exchange factor Sos binds to a phosphotyrosine-containing sequence in the activated receptor via the Grb2 SH2 domain. This interaction recruits Sos to the plasma membrane, where it can stimulate Ras GDP/GTP exchange. The activated Ras-GTP complex then binds to the Raf protein kinase.

From: Pathways of Intracellular Signal Transduction

Cover of The Cell
The Cell: A Molecular Approach. 2nd edition.
Cooper GM.
Sunderland (MA): Sinauer Associates; 2000.
Copyright © 2000, Geoffrey M Cooper.

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