Figure 13.31. Activation of the Akt protein kinase.

Figure 13.31Activation of the Akt protein kinase

Akt is recruited to the plasma membrane by binding to PIP3 via its pleckstrin homology (PH) domain. It is then activated as a result of phosphorylation by another protein kinase (PDK) that also binds PIP3.

From: Pathways of Intracellular Signal Transduction

Cover of The Cell
The Cell: A Molecular Approach. 2nd edition.
Cooper GM.
Sunderland (MA): Sinauer Associates; 2000.
Copyright © 2000, Geoffrey M Cooper.

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