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Squires H, Simpson E, Meng Y, et al. A Systematic Review and Economic Evaluation of Cilostazol, Naftidrofuryl Oxalate, Pentoxifylline and Inositol Nicotinate for the Treatment of Intermittent Claudication in People with Peripheral Arterial Disease. Southampton (UK): NIHR Journals Library; 2011 Dec. (Health Technology Assessment, No. 15.40.)

Cover of A Systematic Review and Economic Evaluation of Cilostazol, Naftidrofuryl Oxalate, Pentoxifylline and Inositol Nicotinate for the Treatment of Intermittent Claudication in People with Peripheral Arterial Disease

A Systematic Review and Economic Evaluation of Cilostazol, Naftidrofuryl Oxalate, Pentoxifylline and Inositol Nicotinate for the Treatment of Intermittent Claudication in People with Peripheral Arterial Disease.

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Appendix 1Literature search strategies

Search strategies were developed to retrieve both RCTs and systematic reviews.

Randomised controlled trials

MEDLINE and MEDLINE(R) In-Process & Other Non-Indexed Citations: Ovid, 1950 to present

  1. Intermittent Claudication/
  2. claudication.tw.
  3. 1 or 2
  4. exp Peripheral Vascular Diseases/
  5. (peripheral adj arterial adj disease$).tw.
  6. (peripheral adj vascular adj disease$).tw.
  7. (atherosclero$ and (PAD or PVD)).tw.
  8. ((arterial adj disease$) and (PAD or PVD)).tw.
  9. or/4-8
  10. Atherosclerosis/dt, th [Drug Therapy, Therapy]
  11. Vascular Diseases/dt, th [Drug Therapy, Therapy]
  12. Vasodilator Agents/
  13. vasodilator$.tw.dh
  14. Platelet Aggregation Inhibitors/
  15. (platelet adj aggregation adj inhibitor$).tw.
  16. Phosphodiesterase Inhibitors/
  17. (phosphodiesterase adj inhibitor$).tw.
  18. Tetrazoles/tu [Therapeutic Use]
  19. or/10-18
  20. 3 and 9 and 19
  21. (pletal or pletaal).tw.
  22. OPC-13013.tw.
  23. 73963-72-1.rn.
  24. or/21-24
  25. 3 and 25
  26. 9 and 25
  27. Nafronyl/
  28. naftidrofuryl$.tw.
  29. naphtidrofuryl.tw.
  30. (nafronyl or naftifurin).tw.
  31. praxilene.tw.
  32. (dusodril or iridus).tw.
  33. 3200-06-4.rn.
  34. or/28-34
  35. 3 and 35
  36. 9 and 35
  37. trental.tw.
  38. oxpentifylline.tw.
  39. (pentoxil or pentofin).tw.
  40. bl-191.tw.
  41. 6493-05-6.rn.
  42. or/38-44
  43. 3 and 45
  44. 9 and 45
  45. Nicotinic Acids/
  46. (inositol adj (nicotinate or hexanicotinate)).tw.
  47. (inositol adj niacinate).tw.
  48. hexopal.tw.
  49. (dilexpal or mesotal or palohex or hexanicotol or esantene or hexanicit or linodil or mesonex or dilcit).tw.
  50. 6556-11-2.rn.
  51. or/48-53
  52. 3 and 54
  53. 9 and 54
  54. 26 or 36 or 46 or 55
  55. 27 or 37 or 47 or 56
  56. 57 or 58
  57. 20 or 59
  58. Randomized controlled trials as Topic/
  59. Randomized controlled trial/
  60. Random allocation/
  61. randomized controlled trial.pt.
  62. Double blind method/
  63. Single blind method/
  64. Clinical trial/
  65. exp Clinical Trials as Topic/
  66. controlled clinical trial.pt.
  67. or/61-69
  68. (clinic$ adj25 trial$).ti,ab.
  69. ((singl$ or doubl$ or treb$ or tripl$) adj (blind$ or mask$)).tw.
  70. Placebos/
  71. Placebo$.tw.
  72. (allocated adj2 random).tw.
  73. or/71-75
  74. 70 or 76
  75. Case report.tw.
  76. Letter/
  77. Historical article/
  78. 78 or 79 or 80
  79. 77 not 81
  80. 60 and 82
  81. exp Animals/
  82. Humans/
  83. 84 not 85
  84. 83 not 86

Broad drug class terms (10–18) were combined with both IC (1–2) and PAD statements (4-8). In addition, terms relating to the drug interventions (synonyms, alternative proprietary names, CAS registry numbers) were combined with either IC (1–2) or PAD terms (4–8). A RCT filter (61–86) was applied to retrieve the highest level of evidence.

Systematic reviews

MEDLINE and MEDLINE(R) In-Process & Other Non-Indexed Citations: Ovid, 1950 to present

61.

meta-analysis as topic/

62.

(meta analy$ or metaanaly$).tw

63.

Meta-Analysis/

64.

(systematic adj (review$1 or overview$)).tw

65.

“Review Literature as Topic”/

66.

or/61-65

67.

(cochrane or embase or psychlit or psyclit or psychinfo or psycinfo or cinahl or cinhal or science citation index or b.i.ds or cancerlit).ab.

68.

((reference adj list$) or bibliograph$ or hand-search$ or (relevant adj journals) or (manual adj search$)).ab.

69.

((selection adj criteria) or (data adj extraction)).ab.

70.

“review”/

71.

69 and 70

72.

comment/ or editorial/ or letter/

73.

Animals/

74.

Humans/

75.

73 and 74

76.

73 not 75

77.

72 or 76

78.

66 or 67 or 68 or 71

79.

78 not 77

80.

60 and 79

Search statements 1–60 of the RCT search strategy above were combined with a systematic reviews methodology filter (statements 61–79).

Economic studies

MEDLINE and MEDLINE(R) In-Process & Other Non-Indexed Citations: Ovid, 1950 to present

61.

exp “Costs and Cost Analysis”/

62.

Economics/

63.

exp Economics, Hospital/

64.

exp Economics, Medical/

65.

Economics, Nursing/

66.

exp models, economic/

67.

Economics, Pharmaceutical/

68.

exp “Fees and Charges”/

69.

exp Budgets/

70.

budget$.tw.

71.

ec.fs.

72.

cost$.ti.

73.

(cost$ adj2 (effective$ or utilit$ or benefit$ or minimi$)).ab.

74.

(economic$ or pharmacoeconomic$ or pharmaco-economic$).ti.

75.

(price$ or pricing$).tw.

76.

(financial or finance or finances or financed).tw.

77.

(fee or fees).tw.

78.

(value adj2 (money or monetary)).tw.

79.

quality-adjusted life years/

80.

(qaly or qalys).af.

81.

(quality adjusted life year or quality adjusted life years).af.

82.

or/61-81

83.

60 and 82

To retrieve evidence of cost-effectiveness studies, an economics filter was applied in place (61–82) of the RCT/SR search strategies above.

Adverse events

MEDLINE and MEDLINE(R) In-Process & Other Non-Indexed Citations: Ovid, 1950 to present

  1. Nafronyl/ae, po, to
  2. Pentoxifylline/ae, po, to
  3. Nicotinic Acids/ae, po, to
  4. or/1-3
  5. (pletal or pletaal).tw.
  6. OPC-13013.tw.
  7. 73963-72-l.rn.
  8. naftidrofuryl$.tw.
  9. naphtidrofuryl.tw.
  10. (nafronyl or naftifurin).tw.
  11. praxilene.tw.
  12. (dusodril or iridus).tw.
  13. 3200-06-4.rn.
  14. trental.tw.
  15. oxpentifylline.tw.
  16. (pentoxil or pentofin).tw.
  17. bl-191.tw.
  18. 6493-05-6.rn.
  19. (inositol adj (nicotinate or hexanicotinate)).tw.
  20. (inositol adj niacinate).tw.
  21. hexopal.tw.
  22. (dilexpal or mesotal or palohex or hexanicotol or esantene or hexanicit or linodil or mesonex or dilcit).tw.
  23. 6556-11-2.rn.
  24. or/5-25
  25. (adverse adj2 (event$ or effect$ or reaction$ or outcome$)).ti,ab.
  26. (adrs or adr or complication$ or harm$ or harmful or risk$ or safe or safety or tolerability or tolerance or tolerate or toxic or toxicity).ti.
  27. ((side or undesirable) adj2 effect$).ti,ab.
  28. (treatment adj2 emergent).ti.
  29. or/27-30
  30. 26 and 31
  31. 4 or 32
  32. exp Animals/
  33. Humans/
  34. 34 not 35
  35. 33 not 36

Two approaches were used in the search for AEs of the four interventions. First, the AE subheadings that are linked to indexed drug names (1–3) and second, free-text terms relating to AEs (27–31) were combined with the intervention terms (5–26).

Quality-of-life studies

MEDLINE and MEDLINE(R) In-Process & Other Non-Indexed Citations: Ovid, 1950 to present

61.

“Quality of Life”/

62.

(qol or (quality adj2 life)).ab,ti.

63.

(value adj2 (money or monetary)).tw.

64.

value of life/

65.

quality adjusted life year/

66.

quality adjusted life.tw.

67.

(qaly$ or qald$ or qale$ or qtime$).tw.

68.

disability adjusted life.tw.

69.

daly$.tw.

70.

health status indicators/

71.

(SF-36 or sf 36 or short form 36 or shortform 36 or sf thirtysix or sf thirty six or shorform thirtysix or shortform thirty six or short form thirtysix or short form thirty six).tw.

72.

(sf 6 or sf6 or short form 6 or shortform 6 or sf six or sfsix or shortform six or short form six).tw.

73.

(sf12 or sf 12 or short form 12 or shortform 12 or sf twelve or sftwelve or shortform twelve or short form twelve).tw.

74.

(sf16 or sf 16 or short form 16 or shortform 16 or sf sixteen or sfsixteen or shortfrom sixteen or short form sixteen).tw.

75.

(sf20 or sf 20 or short form 20 or shortform 20 or sf twenty or sftwenty or shortform twenty or short form twenty).tw.

76.

(euroqol or euro qol or eq5d or eq 5d).tw.

77.

(hql or hqol or h qol or hrqol or hr qol).tw.

78.

(hye or hyes).tw.

79.

health$ year$ equivalent$.tw.

80.

health utilit$.tw.

81.

(hui or hui1 or hui2 or hui3).tw.

82.

disutilit$.tw.

83.

rosser.tw.

84.

(quality adj2 wellbeing).tw.

85.

qwb.tw.

86.

(willingness adj2 pay).tw.

87.

standard gamble$.tw.

88.

time trade off.tw.

89.

time tradeoff.tw.

90.

tto.tw.

91.

letter.pt.

92.

editorial.pt.

93.

comment.pt.

94.

91 or 92 or 93

95.

or/61-90

96.

95 not 94

97.

60 and 96

Search statements 1–60 in the RCT search strategy were combined with the quality-of-life methodology filter (statements 61–96).

Quality-of-life of intermittent claudication

MEDLINE and MEDLINE(R) In-Process & Other Non-Indexed Citations: Ovid, 1950 to present

  1. Intermittent Claudication/
  2. claudication.tw.
  3. 1 or 2
  4. “Quality of Life”/
  5. (qol or (quality adj2 life)).ab,ti.
  6. (value adj2 (money or monetary)).tw.
  7. value of life/
  8. quality adjusted life year/
  9. quality adjusted life.tw.
  10. (qaly$ or qald$ or qale$ or qtime$).tw.
  11. disability adjusted life.tw.
  12. daly$.tw.
  13. health status indicators/
  14. (SF-36 or sf 36 or short form 36 or shortform 36 or sf thirtysix or sf thirty six or shorform thirtysix or shortform thirty six or short form thirtysix or short form thirty six).tw.
  15. (sf 6 or sf6 or short form 6 or shortform 6 or sf six or sfsix or shortform six or short form six).tw.
  16. (sf12 or sf 12 or short form 12 or shortform 12 or sf twelve or sftwelve or shortform twelve or short form twelve).tw.
  17. (sf16 or sf 16 or short form 16 or shortform 16 or sf sixteen or sfsixteen or shortfrom sixteen or short form sixteen).tw.
  18. (sf20 or sf 20 or short form 20 or shortform 20 or sf twenty or sftwenty or shortform twenty or short form twenty).tw.
  19. (euroqol or euro qol or eq5d or eq 5d).tw.
  20. (hql or hqol or h qol or hrqol or hr qol).tw.
  21. (hye or hyes).tw.
  22. health$ year$ equivalent$.tw.
  23. health utilit$.tw.
  24. (hui or hui1 or hui2 or hui3).tw.
  25. disutilit$.tw.
  26. rosser.tw.
  27. (quality adj2 wellbeing).tw.
  28. qwb.tw.
  29. (willingness adj2 pay).tw.
  30. standard gamble$.tw.
  31. time trade off.tw.
  32. time tradeoff.tw.
  33. tto.tw.
  34. letter.pt.
  35. editorial.pt.
  36. comment.pt.
  37. 34 or 35 or 36
  38. or/4-33
  39. 38 not 37
  40. 3 and 39

Searches for studies of patients with IC without treatment were carried out. Terms for IC (1–2) were combined with the quality-of-life filter as shown above (4–39). Records retrieved from the quality-of-life searches with interventions form a sub-set of the records retrieved from these searches.

Quality of life of advanced intermittent claudication

MEDLINE and MEDLINE(R) In-Process & Other Non-Indexed Citations: Ovid, 1950 to present

  1. Intermittent Claudication/
  2. claudication.tw.
  3. (advance$ or severe).tw.
  4. (1 or 2) and 3
  5. critical limb isch?emia.tw.
  6. isch?emic rest pain.tw.
  7. ((CLI or IRP) and (peripheral arterial disease or PAD)).tw.
  8. advanced peripheral arterial disease.tw.
  9. or/4-8
  10. “Quality of Life”/
  11. (qol or (quality adj2 life)).ab,ti.
  12. (value adj2 (money or monetary)).tw.
  13. value of life/
  14. quality adjusted life year/
  15. quality adjusted life.tw.
  16. (qaly$ or qald$ or qale$ or qtime$).tw.
  17. disability adjusted life.tw.
  18. daly$.tw.
  19. health status indicators/
  20. (SF-36 or sf 36 or short form 36 or shortform 36 or sf thirtysix or sf thirty six or shorform thirtysix or shortform thirty six or short form thirtysix or short form thirty six).tw.
  21. (sf 6 or sf6 or short form 6 or shortform 6 or sf six or sfsix or shortform six or short form six).tw.
  22. (sf12 or sf 12 or short form 12 or shortform 12 or sf twelve or sftwelve or shortform twelve or short form twelve).tw.
  23. (sf16 or sf 16 or short form 16 or shortform 16 or sf sixteen or sfsixteen or shortfrom sixteen or short form sixteen).tw.
  24. (sf20 or sf 20 or short form 20 or shortform 20 or sf twenty or sftwenty or shortform twenty or short form twenty).tw.
  25. (euroqol or euro qol or eq5d or eq 5d).tw.
  26. (hql or hqol or h qol or hrqol or hr qol).tw.
  27. (hye or hyes).tw.
  28. health$ year$ equivalent$.tw.
  29. health utilit$.tw.
  30. (hui or hui1 or hui2 or hui3).tw.
  31. disutilit$.tw.
  32. rosser.tw.
  33. (quality adj2 wellbeing).tw.
  34. qwb.tw.
  35. (willingness adj2 pay).tw.
  36. standard gamble$.tw.
  37. time trade off.tw.
  38. time tradeoff.tw.
  39. tto.tw.
  40. letter.pt.
  41. editorial.pt.
  42. comment.pt.
  43. 40 or 41 or 42
  44. or/10-39
  45. 44 not 43
  46. 9 and 45

Search terms for advanced IC (1–9) were combined with the quality-of-life methodology filter (9–45).

© 2011, Crown Copyright.

Included under terms of UK Non-commercial Government License.

Bookshelf ID: NBK98437

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