Figure 7.26. Synthesis of N-linked glycoproteins.

Figure 7.26Synthesis of N-linked glycoproteins

The first step in glycosylation is the addition of an oligosaccharide consisting of 14 sugar residues to a growing polypeptide chain in the endoplasmic reticulum (ER). The oligosaccharide (which consists of two N-acetylglucosamine, nine mannose, and three glucose residues) is assembled on a lipid carrier (dolichol phosphate) in the ER membrane. It is then transferred as a unit to an acceptor asparagine residue of the polypeptide.

From: Protein Folding and Processing

Cover of The Cell
The Cell: A Molecular Approach. 2nd edition.
Cooper GM.
Sunderland (MA): Sinauer Associates; 2000.
Copyright © 2000, Geoffrey M Cooper.

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