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Cooper GM. The Cell: A Molecular Approach. 2nd edition. Sunderland (MA): Sinauer Associates; 2000.

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Cover of The Cell

The Cell: A Molecular Approach. 2nd edition.

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Figure 15.21. The Raf oncogene protein.

Figure 15.21The Raf oncogene protein

The Raf proto-oncogene protein consists of an amino-terminal regulatory domain and a carboxy-terminal protein kinase domain. In the viral Raf oncogene protein, the regulatory domain has been deleted and replaced by viral Gag sequences. As a result, the Raf kinase domain is constitutively active, causing cell transformation.

From: Oncogenes

Copyright © 2000, Geoffrey M Cooper.


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