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Cover of The Cell

The Cell, 2nd edition

A Molecular Approach

.

Boston University
Sunderland (MA): Sinauer Associates; .
ISBN-10: 0-87893-106-6

Excerpt

As in the first edition, The Cell is focused on the molecular biology of cells as a unifying theme, with specialized topics discussed throughout the book as examples of more general principles. Aspects of developmental biology, the immune system, the nervous system, and plant biology are thus discussed in their broader biological context in chapters covering areas such as genome structure, gene expression, DNA rearrangements, the plasma membrane, cell signaling, and the cell cycle. Relationships between cell biology and medicine are similarly discussed throughout the text, as well as being highlighted in the Molecular Medicine essays that are included as a special feature in each chapter. These discussions illustrate the striking impact of molecular and cellular biology on human health, and are intended to stimulate as well as inform those students interested in medicine.

Contents

  • Acknowledgments
  • Preface
  • Part I. Introduction
    • Chapter 1. An Overview of Cells and Cell Research
      • The Origin and Evolution of Cells
      • Cells As Experimental Models
      • Tools of Cell Biology
      • Summary
      • Questions
      • References and Further Reading
    • Chapter 2. The Chemistry of Cells
      • The Molecular Composition of Cells
      • The Central Role of Enzymes as Biological Catalysts
      • Metabolic Energy
      • The Biosynthesis of Cell Constituents
      • Cell Membranes
      • Summary
      • Questions
      • References and Further Reading
    • Chapter 3. Fundamentals of Molecular Biology
      • Heredity, Genes, and DNA
      • Expression of Genetic Information
      • Recombinant DNA
      • Detection of Nucleic Acids and Proteins
      • Gene Function in Eukaryotes
      • Summary
      • Questions
      • References and Further Reading
  • Part II. The Flow of Genetic Information
    • Chapter 4. The Organization of Cellular Genomes
      • The Complexity of Eukaryotic Genomes
      • Chromosomes and Chromatin
      • The Sequences of Complete Genomes
      • The Human Genome
      • Summary
      • Questions
      • References and Further Reading
    • Chapter 5. Replication, Maintenance, and Rearrangements of Genomic DNA
      • DNA Replication
      • DNA Repair
      • Recombination Between Homologous DNA Sequences
      • DNA Rearrangements
      • Summary
      • Questions
      • References and Further Reading
    • Chapter 6. RNA Synthesis and Processing
      • Transcription in Prokaryotes
      • Eukaryotic RNA Polymerases and General Transcription Factors
      • Regulation of Transcription in Eukaryotes
      • RNA Processing and Turnover
      • Summary
      • Questions
      • References and Further Reading
    • Chapter 7. Protein Synthesis, Processing, and Regulation
      • Translation of mRNA
      • Protein Folding and Processing
      • Regulation of Protein Function
      • Protein Degradation
      • Summary
      • Questions
      • References and Further Reading
  • Part III. Cell Structure and Function
    • Chapter 8. The Nucleus
      • The Nuclear Envelope and Traffic between the Nucleus and Cytoplasm
      • Internal Organization of the Nucleus
      • The Nucleolus
      • The Nucleus during Mitosis
      • Summary
      • Questions
      • References and Further Reading
    • Chapter 9. Protein Sorting and Transport - The Endoplasmic Reticulum, Golgi Apparatus, and Lysosomes
      • The Endoplasmic Reticulum
      • The Golgi Apparatus
      • The Mechanism of Vesicular Transport
      • Lysosomes
      • Summary
      • Questions
      • References and Further Reading
    • Chapter 10. Bioenergetics and Metabolism - Mitochondria, Chloroplasts, and Peroxisomes
      • Mitochondria
      • The Mechanism of Oxidative Phosphorylation
      • Chloroplasts and Other Plastids
      • Photosynthesis
      • Peroxisomes
      • Summary
      • Questions
      • References and Further Reading
    • Chapter 11. The Cytoskeleton and Cell Movement
      • Structure and Organization of Actin Filaments
      • Actin, Myosin, and Cell Movement
      • Intermediate Filaments
      • Microtubules
      • Microtubule Motors and Movements
      • Summary
      • Questions
      • References and Further Reading
    • Chapter 12. The Cell Surface
      • Structure of the Plasma Membrane
      • Transport of Small Molecules
      • Endocytosis
      • Cell Walls and the Extracellular Matrix
      • Cell-Cell Interactions
      • Summary
      • Questions
      • References and Further Reading
  • Part IV. Cell Regulation
    • Chapter 13. Cell Signaling
      • Signaling Molecules and Their Receptors
      • Functions of Cell Surface Receptors
      • Pathways of Intracellular Signal Transduction
      • Signal Transduction and the Cytoskeleton
      • Signaling in Development and Differentiation
      • Regulation of Programmed Cell Death
      • Summary
      • Questions
      • References and Further Reading
    • Chapter 14. The Cell Cycle
      • The Eukaryotic Cell Cycle
      • Regulators of Cell Cycle Progression
      • The Events of M Phase
      • Meiosis and Fertilization
      • Cell Proliferation in Development and Differentiation
      • Summary
      • Questions
      • References and Further Reading
    • Chapter 15. Cancer
      • The Development and Causes of Cancer
      • Tumor Viruses
      • Oncogenes
      • Tumor Suppressor Genes
      • Applications of Molecular Biology to Cancer Prevention and Treatment
      • Summary
      • Questions
      • References and Further Reading
  • Glossary

By agreement with the publisher, this book is accessible by the search feature, but cannot be browsed.

Copyright © 2000, Geoffrey M Cooper.
Bookshelf ID: NBK9839

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