Table 11-1Principles for addressing common challenges when evaluating genetic tests used as predictive indicators

Principle 1: Use an organizing framework appropriate for genetic tests.
Principle 2: Develop analytic frameworks that reflect the predictive nature of genetic tests and incorporate appropriate outcomes.
Principle 3: Search databases appropriate for genetic tests.
Principle 4: Consult with experts to determine which technical issues are important to address in assessing genetic tests.
Principle 5: Distinguish between functional assays and DNA-based assays to determine important technical issues.
Principle 6: Evaluate case-control studies carefully for potential selection bias.
Principle 7: Determine the added value of the genetic test over existing risk assessment approaches.
Principle 8: Understand statistical issues of particular relevance to genetic tests.

From: Chapter 11, Challenges in and Principles for Conducting Systematic Reviews of Genetic Tests Used as Predictive Indicators

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Methods Guide for Medical Test Reviews [Internet].
Chang SM, Matchar DB, Smetana GW, et al., editors.

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