Figure 1 is an analytic framework that depicts the events that postmenopausal women experience when they are treated with hormone therapy to prevent chronic conditions. The hormone therapy is either estrogen only or estrogen plus progestin. The figure shows that women could experience improved health outcomes or adverse effects. The patient population of interest is postmenopausal women. The outcomes of interest are improved health ouctomes, improved mortality, or adverse effects.

Figure 1Analytic Framework and Key Questions

Key Questions

1. What are the benefits of menopausal hormone therapy when used to prevent chronic conditions? Potential benefits include reduced fractures and colorectal cancer.

2. What are the harms of menopausal hormone therapy when used to prevent chronic conditions? Potential harms include coronary heart disease events, stroke, cognitive decline, venous thromboembolism, breast cancer, endometrial cancer, ovarian cancer, and cholecystitis.

3. Do benefits and harms differ by subgroups? Subgroups include women with premature menopause; women with surgical menopause; age of use; types, doses, and modes of delivery of hormones; and presence of comorbidities.

From: 2, METHODS

Cover of Menopausal Hormone Therapy for the Primary Prevention of Chronic Conditions
Menopausal Hormone Therapy for the Primary Prevention of Chronic Conditions: Systematic Review to Update the 2002 and 2005 U.S. Preventive Services Task Force Recommendations.
Evidence Syntheses, No. 93.
Nelson HD, Walker M, Zakher B, et al.

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