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Excerpt
Animals are widely used in neuroscience research to explore normal and abnormal biological mechanisms of nervous system function, to identify the genetic basis of disease states, and to provide models of human disorders and diseases for the development of new treatments. Numerous laws, policies, and regulations are in place governing the use of animals in research. These measures are intended to ensure the humane care and use of animals, including the implementation of practical steps to use the smallest number of animals necessary to achieve significant results while minimizing pain and distress. Many animal care and use issues are generic to all types of biomedical research; however, animal regulations have implications specific to neuroscience research.
To consider these issues from a global perspective, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders, in collaboration with the National Research Council Committee on Science, Technology, and Law and the Institute for Laboratory Animal Research, convened the workshop “U.S. and European Animal Research Regulations: Impact on Neuroscience Research.” Held at the Kavli Royal Society International Centre in Buckinghamshire, UK, on July 26–27, 2011, the workshop brought together neuroscientists, legal scholars, administrators, and other key stakeholders to discuss current and emerging trends in animal regulations as they apply to the neurosciences.
Contents
- THE NATIONAL ACADEMIES
- U.S. AND EUROPEAN ANIMAL RESEARCH REGULATIONS: IMPACT ON NEUROSCIENCE RESEARCH PLANNING COMMITTEE
- FORUM ON NEUROSCIENCE AND NERVOUS SYSTEM DISORDERS
- Reviewers
- 1. Introduction and Overview
- 2. The Evolving Regulatory Environment
- 3. Emerging Legal Trends Impacting Animal Research
- 4. Animals in Neuroscience Research
- 5. Advancing the 3Rs in Neuroscience Research
- 6. Public Engagement and Animal Research Regulations
- 7. Core Principles for the Care and Use of Animals in Research
- 8. Summary of Workshop Topics
- SESSION I INTERNATIONAL ANIMAL RESEARCH REGULATIONS
- SESSION II FREEDOM OF INFORMATION LAWS
- SESSION III THE ROLE FOR ANIMALS IN NEUROSCIENCE RESEARCH
- SESSION IV REPLACEMENT, REFINEMENT, AND REDUCTION IN NEUROSCIENCE RESEARCH
- SESSION V BUILDING PUBLIC CONFIDENCE
- SESSION VI CORE PRINCIPLES TO ACHIEVE CONSISTENT ANIMAL CARE AND USE OUTCOMES
- APPENDIXES
Rapporteurs: Diana E. Pankevich, Theresa M. Wizemann, Anne-Marie Mazza, Bruce M. Altevogt
This project was supported by contracts between the National Academy of Sciences and the Alzheimer’s Association; AstraZeneca Pharmaceuticals, Inc.; CeNeRx Biopharma; the Department of Health and Human Services’ National Institutes of Health (NIH, Contract Nos. N01-OD-4-2139) through the National Institute on Aging, National Institute on Alcohol Abuse and Alcoholism, National Institute on Drug Abuse, National Eye Institute, NIH Blueprint for Neuroscience Research, National Institute of Mental Health, and National Institute of Neurological Disorders and Stroke; Eli Lilly and Company; Foundation for the National Institutes of Health; GE Healthcare, Inc.; GlaxoSmithKline, Inc.; Johnson & Johnson Pharmaceutical Research and Development, LLC; Lundbeck Research USA; Merck Research Laboratories; The Michael J. Fox Foundation for Parkinson’s Research; the National Multiple Sclerosis Society; the National Science Foundation (Contract No. OIA-0753701); Pfizer Inc.; and the Society for Neuroscience.
Suggested citation:
IOM (Institute of Medicine) and NRC (National Research Council). 2012. International animal research regulations: Impact on neuroscience research: Workshop summary. Washington, DC: The National Academies Press.
The views presented in this publication are those of the editors and attributing authors and do not necessarily reflect the view of the organizations or agencies that provided support for this project.
NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine.
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- International Animal Research RegulationsInternational Animal Research Regulations
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