• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

Table 8Monotherapy versus combined therapy studies showing the comparison and treatment interventions grouped by type of intervention

StudyMonotherapyCombined Therapy
Licht,119 2002Sertraline + Placebo
Sertraline (higher dose) + Placebo
Sertraline + Mianserin
Altamura,82,83 2008SSRI + Placebo (saline)SSRI + Citalopram (intravenous)
Add nonSSRI Antidepressant
Altamura,82,83 2008SSRI + Placebo (saline)SSRI + Clomipramine (intravenous)
Trivedi,113 2006
Rush,44 2006*
Thase,110 2007*
Switching to new monotherapy (Buproprion/Venlaxfine/Sertraline/CBT)Citalopram + Buproprion
Fava,118 2002Fluoxetine + PlaceboFluoxetine + Desipramine
Fluoxetine + Lithium
Fava,98 1994FluoxetineFluoxetine + Desipramine
Fluoxetine + Lithium
Add Augmenting Agent
Preskorn,80 2008Paroxetine + PlaceboParoxetine + CP-101606
George,84 2008Current SSRI +placeboCurrent SSRI + Mecamylamine Hydrochloride
Michelson,87,101,132 2007Sertraline + PlaceboSertraline + Atomoxetine
Shapira,89 2006SSRI (Fluoxetine/Fluvoxamine/Paroxetine) + PlaceboCurrent SSRI + Phenytoin
Seidman,91 2005SSRI + Placebo injectionCurrent SSRI + Testosterone injection
Berman,109 2007
Marcus,105,131 2008
Thase,126
Berman,79
Switched to new SSRI
Escilatopram/Fluoxetine/Sertraline/Venlafaxine + Placebo
Switched to new SSRI (Escilatopram/Fluoxetine/Sertraline/Venlafaxine) + Aripiprazole
Fava,114 2005SSRI + placeboSSRI + Modafinil
Nemets,123 1999SSRI + placebo (glucose)SSRI + Inositiol
Dunner,86 2007SertralineSertraline + Ziprasidone 60mg/d
Sertraline + Ziprasidone 80mg/d
Buspirone
Appelberg,120 2001SSRI + placeboSSRI + Buspirone
Landén,97 1998
Landén,92 2005
Landén,130 1999
Citalopram or ParoxetineCitalopram or Paroxetine + Buspirone
Rush,44 2006
Trivedi,113 2006
Thase,110 2007
Switching to new monotherapy (Sertraline/Venlafaxine/Buproprion/CBT)Citalopram + Buspirone
StudySSRIAdd SSRI
Mianserin
Licht,119 2002Sertraline Dose 1 + Placebo
Sertraline Dose 2 + Placebo
Sertraline + Mianserin
Ferreri,121 2001FluoxetineFluoxetine + Mianserin
Lithium
Baumann,124 1996Citalopram + PlaceboCitalopram + Lithium
Bondolfi,112 2006ParoxetineParoxetine + Lithium
Switch to Venlaxafine
Fava,118 2002Fluoxetine + PlaceboFluoxetine + Lithium
Fluoxetine + Desipramine
Fava,98 1994FluoxetineFluoxetine + Lithium
Fluoxetine + Desipramine
Atypical Anti-psychotics
Thase,88 2007Fluoxetine
Olanzapine
Fluoxetine + Olanzapine
Shelton,122 2001Olanzapine + Placebo
Fluoxetine + Placebo
Fluoxetine + Olanzapine
Keitner,95 2009SSRI + Risperidone
Mahmoud,108 2007SSRI + PlaceboSSRI + Risperidone
Bauer134,188 2010Any SSRI + PlaceboAny SSRI + Quetiapine XR 150 mg
Any SSRI + Quetiapine XR 300 mg
Pindolol
Perry,93 2004Fluoxetine/Setraline/Paroxetine + placebo (lactose powder)Fluoxetine/Setraline/Paroxetine + Pindolol
Sokolski,96 2004Paroxetine + PlaceboParoxetine + Pindolol
Adding Non-pharmacological Treatment
Wiles,94 2008Any SSRISSRI + CBT
Carta,127 2008Any SSRISSRI + Exercise
Lynch,128 2007Paroxetine/Sertraline/FluoxetineSSRI + DBT
Thase,110 2007
Rush,44 2006
Trivedi,113 2006
Switching to new monotherapy (Sertraline/Venlaxfine/Buproprion/CBT)Citalopram + CBT
Reynolds133,135,137 2010Increase Escitalopram dose + EducationIncrease Escitalopram dose + Education + Interpersonal Therapy

CBT = cognitive behavioral therapy; DBT = dialectical behavior therapy; SSRI = selective serotonin reuptake inhibitors

*

Indicates that comparison arm is not the SSRI prior to the switch.

Indicates that comparison arm is not the SSRI prior to the switch.

From: Results

Cover of Treatment for Depression After Unsatisfactory Response to SSRIs
Treatment for Depression After Unsatisfactory Response to SSRIs [Internet].
Comparative Effectiveness Reviews, No. 62.
Santaguida PL, MacQueen G, Keshavarz H, et al.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.