Table 27Combined therapy versus combined therapy (pharmacological and nonpharmacological)

Quality AssessmentSummary of FindingsImportance
No. of PatientsEffectQuality
No. of StudiesDesignLimitationsInconsistencyIndirectnessImprecisionOther ConsiderationsCombo 1Combo 2RR or(% A/E)
Outcome Response
644,82,83,86,98,110,118,125RCT/CCTLimitiationsConsistentDirectImpreciseDiverse interventions434377RR range 0.37 to 1.36LOWCritical
Outcome Remission
644,82,83,86,98,110,118,125RCT/CCTLimitationsConsistentDirectImpreciseDiverse interventions344286RR range 0.69 to 1.0LOWCritical
Outcome of Suicidality
1113RCT/CCTLimitationsN/ADirectN/AN/AN/A% range (0.4 and 1.4)InsufficientCritical
Outcome of Weight Gain
0RCT/CCTLimitationsN/ADirectN/AN/AN/ANRInsufficientImportant
Outcome of Sexual Dysfunction
0RCT/CCTLimitationsN/ADirectN/AN/AN/ANRInsufficientImportant

A/E = adverse event; CCT = clinical controlled trial; N/A = not applicable; No. = number; NR = not reported; RCT = randomized controlled trial; RR = relative risk

From: Results

Cover of Treatment for Depression After Unsatisfactory Response to SSRIs
Treatment for Depression After Unsatisfactory Response to SSRIs [Internet].
Comparative Effectiveness Reviews, No. 62.
Santaguida PL, MacQueen G, Keshavarz H, et al.

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