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Institute of Medicine (US) and National Research Council (US) Committee on the Use of Chimpanzees in Biomedical and Behavioral Research; Altevogt BM, Pankevich DE, Shelton-Davenport MK, et al., editors. Chimpanzees in Biomedical and Behavioral Research: Assessing the Necessity. Washington (DC): National Academies Press (US); 2011.

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Chimpanzees in Biomedical and Behavioral Research: Assessing the Necessity.

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CInformation-Gathering Agendas

May 26, 2011

Keck Center, Room 109

500 Fifth Street, NW

Washington, DC 20001

BACKGROUND AND OVERVIEW

Session Objectives: Obtain a better understanding of the background to the study and the charge to the committee. Receive a briefing from NIH about existing areas of science where chimpanzee research is supported. Hear from stakeholders about the use of chimpanzees in research, as specifically related to the committee’s charge.
1:00 p.m.Welcome and Introductions
 John Stobo, Committee Chair
 Senior Vice President
 Health Sciences and Services
 University of California System
1:10 p.m.Background and Charge to the Committee
 Sally Rockey
 Deputy Director for Extramural Research
 National Institutes of Health
1:30 p.m.Committee Discussion with Sponsor
 John Stobo, Committee Chair
 Senior Vice President
 Health Sciences and Services
 University of California System
2:15 p.m.NIH-Supported Chimpanzee Biomedical Research
 Harold Watson
 Deputy Director
 Division of Comparative Medicine
 National Center for Research Resources, NIH
2:35 p.m.Discussion with the Committee
2:45 p.m.BREAK
3:15 p.m.NIH-Supported Chimpanzee Behavioral Research
 Richard Nakamura
 Scientific Director
 National Institute of Mental Health, NIH
3:35 p.m.Discussion with the Committee
3:45 p.m.Panel Discussion: Is there a continued need for chimpanzee research?
 John Pippin
 Senior Medical and Research Adviser
 Physicians Committee for Responsible Medicine
 Jarrod Bailey
 Science Director
 New England Anti-Vivisection Society
 Kevin Kregel
 Professor, Departments of Integrative
 Physiology and Radiation Oncology
 University of Iowa
 Chair, Animal Issues Committee
 Federation of American Societies for Experimental Biology
4:15 p.m.Discussion with the Committee
4:45 p.m.ADJOURN

August 11, 2011

Keck Center, Room 100

500 Fifth Street, NW

Washington, DC 20001

Meeting Objectives:
  • To obtain background data on the current use of chimpanzees in biomedical and behavioral research.
  • To explore potential alternative models to chimpanzees.
  • To seek public comment about the scientific need for chimpanzees in biomedical and behavioral research.
8:00 a.m.Welcome and Meeting Objectives
 Jeffrey Kahn, Committee Chair
 Director and Professor
 Maas Family Endowed Chair in Bioethics
 Center for Bioethics
 University of Minnesota

SESSION I: THE CHIMPANZEE

Session Objectives: Understand chimpanzee behavior and genetics and their role in biomedical research. Compare chimpanzees both to other models and to humans. Explore the usefulness of the chimpanzee as a model for biomedical and behavioral research, specifically for understanding human diseases and disorders. Discuss what scientific alternatives exist should the chimpanzee no longer be an available model.
 Jay Kaplan, Session Chair
 Professor of Pathology (Comparative Medicine), Translational Science and Anthropology
 Wake Forest University Primate Center and Wake Forest Translational Science Institute
 Wake Forest School of Medicine
8:10 a.m.Chimpanzee Behavior
 Frans de Waal
 C.H. Candler Professor of Primate Behavior
 Department of Psychology
 Emory University
8:30 a.m.Chimpanzee Genetics
 Jeffrey Rogers
 Associate Professor
 Department of Molecular and Human Genetics
 Baylor College of Medicine
8:50 a.m.Chimpanzee Biomedical Research
 Robert Purcell
 Chief, Hepatitis Viruses Section
 Laboratory of Infectious Diseases
 National Institute of Allergy and Infectious Diseases
9:10 a.m.Panel Discussion with Committee
  • What scientific alternatives exist should the chimpanzee no longer be an available model?
9:40 a.m.BREAK

SESSION II: BEHAVIORAL RESEARCH

Session Objective: Review current use of chimpanzees for behavioral research. Explore alternative models also used in this research area.
 Robert Sapolsky, Session Chair
 Professor of Biology, Neurology and Neurological Sciences
 Stanford University
9:50 a.m.PANELISTS [15 min/talk]
Chimpanzee Social Behavior and Communication
 William Hopkins
 Professor
 Department of Psychology
 Agnes Scott College
Chimpanzee Learning and Memory
 Charles Menzel
 Senior Research Scientist
 Language Research Center
 Georgia State University
Potential for Non-Human Primates in Behavioral Research
 Mark Moss
 Professor and Chair
 Department of Anatomy and Neurobiology
 Boston University
Chimpanzee Research in Zoos and Sanctuaries
 Brian Hare
 Assistant Professor
 Department of Evolutionary Anthropology
 Duke University
10:50 a.m.Panel Discussion with Committee
  • What scientific alternatives exist should the chimpanzee no longer be an available model?
  • How long would it take for science to catch up if the chimpanzee were no longer available?

SESSION III: PUBLIC COMMENT

Session Objectives: Seek public comment from interested stakeholders about the continued and potential future need for chimpanzees in biomedical and behavioral research.

NOTE: To accommodate requests, speakers will be strictly limited to 3 minutes.

 Jeffrey Kahn, Committee Chair
 Director and Professor
 Maas Family Endowed Chair in Bioethics Center for Bioethics
 University of Minnesota
11:20 a.m.Public Comments
 Alice Ra’anan
 Director of Government Affairs and Science Policy
 The American Physiological Society
 Anne Deschamps
 Science Policy Analyst
 Federation of American Societies for Experimental Biology
 Justin Goodman
 Associate Director
 People for the Ethical Treatment of Animals
 Laura Bonar
 Program Director
 Animal Protection of New Mexico
 Stephen Ross
 Assistant Director, Lester Fisher Center for the Study and Conservation of Apes
 Lincoln Park Zoo
 Raija Bettauer
 Bettauer BioMed Research
 Pamela Osenkowski
 Director of Science Programs
 National Anti-Vivisection Society
 Sue Leary
 President
 Alternatives Research & Development Foundation
 Theodora Capaldo
 President/Executive Director
 New England Anti-Vivisection Society/Project Release & Restitution
 Eric Kleiman
 Research Director
 In Defense of Animals
 Ryan Merkley
 Associate Director of Research Policy
 Physicians Committee for Responsible Medicine
 Matthew Bailey
 Vice President
 National Association for Biomedical Research
 Joseph Erwin
 Consulting Primatologist
 Kathleen Conlee
 Director of Program Management
 The Humane Society of the United States
 Beth Cataldo
 Director
 Cetacean Society USA
 Cathy Liss
 President
 Animal Welfare Institute
 David DeGrazia
 Professor of Philosophy
 George Washington University
 C. James Mahoney
 Research Professor
 New York University School of Medicine
12:20 p.m.LUNCH
SPECIAL LECTURE
1:00 p.m.Chimpanzees in Biomedical and Behavioral Research
 Jane Goodall (via video conference)
 Founder
 Jane Goodall Institute
1:30 p.m.Discussion with Committee

SESSION IV: HEPATITIS

Session Objectives: Review the role of chimpanzees in hepatitis research. Explore alternative models also used in this research area.
 Diane Griffin, Session Chair
 Professor and Chair
 Department of Molecular Microbiology and Immunology
 Johns Hopkins Bloomberg School of Public Health
1:40 p.m.PANELISTS [15 min/talk]
The Current State of Hepatitis Research
 Robert Lanford
 Scientist
 Department of Virology and Immunology
 Texas Biomedical Research Institute
The Next Drug for Hepatitis B and C
 Christopher Walker
 Professor of Pediatrics
 Nationwide Children’s Hospital
 The Ohio State University
Cellular and Molecular Technique Advances in Hepatitis Research
 Stanley Lemon
 Professor of Medicine
 Division of Infectious Diseases
 University of North Carolina School of Medicine
Humanized Mice for the Study of Human Infectious Diseases
 Alexander Ploss
 Research Assistant Professor
 Laboratory of Virology and Infectious Disease
 The Rockefeller University
From Chimpanzee to Human—Translational Research in Viral Hepatitis
 Eugene Schiff
 Leonard Miller Professor of Medicine
 Director, Schiff Liver Institute/Center for Liver Disease
 University of Miami Medical School
2:55 p.m.Panel Discussion with Committee
  • What scientific alternatives exist should the chimpanzee no longer be an available model?
  • How long would it take for science to catch up if the chimpanzee were no longer available?
3:40 p.m.BREAK

SESSION V: INFECTIOUS DISEASES

Session Objectives: Review the role of chimpanzees in infectious disease research. Explore alternative models also used in this research area.
 John Bartlett, Session Chair
 Professor
 Department of Medicine
 Johns Hopkins University School of Medicine
4:00 p.m.PANELISTS [15 min/talk]
The Role of Chimpanzees in HIV Research
 Nancy Haigwood
 Professor of Microbiology and Immunology
 Director
 Oregon National Primate Research Center
The Role of Chimpanzees in RSV Research
 Peter Collins
 Director
 RNA Viruses Section
 National Institute of Allergy and Infectious Diseases
Current Experimental Models for Malaria Vaccine Development
 Ann-Marie Cruz
 Program Officer, Research and Development
 PATH Malaria Vaccine Initiative
Monoclonal Antibody Therapeutics
 Theresa Reynolds
 Director
 Safety Assessment
 Genentech
Alternative Models for Infectious Disease Research
 Robert Hamatake
 Director of HCV Biology
 GlaxoSmithKline
5:15 p.m.Panel Discussion with Committee
  • What scientific alternatives exist should the chimpanzee no longer be an available model?
  • How long would it take for science to catch up if the chimpanzee were no longer available?
6:00 p.m.ADJOURN

August 12, 2011

Keck Center, Room 100

500 Fifth Street, NW

Washington, DC 20001

Meeting Objectives:

  • To obtain background data on the current use of chimpanzees in biomedical and behavioral research
  • To explore potential alternative models to chimpanzees
  • To seek public comment about the scientific need for chimpanzees in biomedical and behavioral research

SESSION VI: POTENTIAL FUTURE NEEDS

Session Objectives: Explore potential future needs for chimpanzees in biomedical and behavioral research. Consider emerging threats and novel technologies.
 Edward Harlow, Session Chair
 Special Assistant to the Director
 National Cancer Institute
8:30 a.m.PANELISTS [15 min/talk]
Surveying the Future of Chimpanzee Research
 Thomas J. R Owell
 Director
 New Iberia Research Center
 University of Louisiana at Lafayettte
Is Chimpanzee Research Critical to the Health Security of the United States?
 Joseph Bielitzki
 Associate Director
 Office of Research and Commercialization
 University of Central Florida
The Role of Chimpanzees in Biodefense Research— DoD Perspective
 James Swearengen
 Director (retired)
 Comparative Medicine Veterinarian
 National Biodefense Analysis and Countermeasures Center
The Role of Chimpanzees in Biodefense Research— NIH Perspective
 Michael Kurilla
 Director
 Office of Biodefense Research Affairs
 National Institutes of Health
9:45 a.m.Discussion with the Committee
  • In the event of a public health emergency, what would the consequences be if there were no chimpanzees available for biomedical research?
  • What would the impact be if chimpanzees were unavailable for testing during drug development and research?
  • How long would it take for science to catch up if the chimpanzee were no longer available?
10:45 a.m.ADJOURN
Copyright © 2011, National Academy of Sciences.
Bookshelf ID: NBK91446
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