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Belinson S, Mauger Rothenberg B, Chopra R, et al. Future Research Needs for Hematopoietic Stem-Cell Transplantation in the Pediatric Population: Identification of Future Research Needs From Comparative Effectiveness Review No. 48 [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2012 Feb. (Future Research Needs Papers, No. 10.)

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Future Research Needs for Hematopoietic Stem-Cell Transplantation in the Pediatric Population: Identification of Future Research Needs From Comparative Effectiveness Review No. 48 [Internet].

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Appendix DSearch Strategy for Recently Published and Ongoing Studies

The search strategy was the same one as was used in the BCBSA TEC HSCT CER with dates starting 10/09/09 through January 2011.

All Child: 0-18 years=3709

#107.

Search #104 AND #106

#106.

Search “Humans”[Mesh]

#104.

Search #102 AND #103

#103.

Search #55 OR #88 OR #90 OR #101

#102.

Search #45 OR #47

#101.

Search “Fabry Disease” OR “Fabry's disease” OR “Farber Lipogranulomatosis” OR “Fabry Disease” OR “Fabry's disease” OR “Farber Lipogranulomatosis” OR Gangliosidos* OR “Sandhoff Disease” OR “sandhoff's disease” OR “Gaucher Disease” OR “gaucher's disease” OR “Niemann-Pick Disease*” OR “Tay-Sachs Disease” OR Aspartylglucosaminuria OR “beta-Mannosidosis” OR Mucolipidos* OR “Wolman Disease” OR “Ceroid Lipofuscinos*” OR “Ceroid-Lipofuscinos*” OR galactosialidosis OR Cystinosis OR “Sialic Acid Storage Disease” OR “salla disease” OR “peroxisomal storage disorder*” OR adrenomyeloneuropath* OR “immune cytopenia*”

#90.

Search “Ewing's Sarcoma” OR “Wilms Tumor” OR Rhabdomyosarcoma* OR Retinoblastoma* OR Medulloblastoma* OR PNET OR “Primitive Neuroectodermal Tumor*” OR Astrocytoma* OR Mucopolysaccharidos* OR Sphingolipidos* OR “Lysosomal Storage Disease*” OR “Glycogen Storage Disease*” OR “Niemann-Pick Disease*” OR Adrenoleukodystrophy OR “Juvenile Rheumatoid Arthritis” OR “Systemic Lupus Erythematosus” OR SLE OR Scleroderma OR “Crohn Disease” OR “Crohn's disease” OR “Autoimmune Disease*”

#88.

Search (((((((((“Mucopolysaccharidoses”[Mesh] OR “Sphingolipidoses”[Mesh]) OR “Lysosomal Storage Diseases”[Mesh]) OR “Glycogen Storage Disease”[Mesh]) OR “Niemann-Pick Diseases”[Mesh]) OR “Adrenoleukodystrophy”[Mesh]) OR “Arthritis, Juvenile Rheumatoid”[Mesh]) OR “Lupus Erythematosus, Systemic”[Mesh]) OR “Scleroderma, Systemic”[Mesh]) OR “Crohn Disease”[Mesh]) OR “Autoimmune Diseases”[Mesh]

#55.

Search (((((“Sarcoma, Ewing's”[Mesh] OR “Wilms Tumor”[Mesh]) OR “Rhabdomyosarcoma”[Mesh]) OR “Retinoblastoma”[Mesh]) OR “Medulloblastoma”[Mesh]) OR “Neuroectodermal Tumors, Primitive”[Mesh]) OR “Astrocytoma”[Mesh]

#47.

Search “stem cell*” OR “bone marrow”

#45.

Search “Bone Marrow Transplantation”[Mesh] OR (“Hematopoietic Stem Cell Transplantation”[Mesh] OR “Peripheral Blood Stem Cell Transplantation”[Mesh] OR “Cord Blood Stem Cell Transplantation”[Mesh] OR “Stem Cell Transplantation”[Mesh])

Additional searching was done to obtain information on comparators in the following diseases:

Diabetes

#15.

Search (#10 AND #13) NOT #5 Limits: Humans, Clinical Trial, Editorial, Practice Guideline, Randomized Controlled Trial, Case Reports, Comparative Study, Controlled Clinical Trial, Guideline, English, All Infant: birth-23 months, All Child: 0-18 years, Publication Date from 1995/10/01 to 2010/07/12

#14.

Search (#10 AND #13) NOT #5

#13.

Search “Immunosuppression”[Mesh] OR immunomodulation OR immunosuppressant OR immunosuppressive OR “immune modulation” OR “immune suppression”

#10.

Search “Diabetes Mellitus, Type 1”[Mesh] OR (“type 1” AND (diabetes OR diabetic OR DM)) OR “juvenile diabetes”

#5.

Search “Bone Marrow Transplantation”[Mesh] OR (“Stem Cell Transplantation”[Mesh] OR “Peripheral Blood Stem Cell Transplantation”[Mesh] OR “Cord Blood Stem Cell Transplantation”[Mesh] OR “Hematopoietic Stem Cell Transplantation”[Mesh]) OR “bone marrow transplant*” OR “stem cell support” OR “stem cell transplant*”

Other Autoimmune Diseases

#23.

Search (#20 AND #13) NOT #5 AND (severe OR refractory OR “poor prognosis”) Limits: Humans, Clinical Trial, Editorial, Practice Guideline, Randomized Controlled Trial, Case Reports, Comparative Study, Controlled Clinical Trial, Guideline, English, All Infant: birth-23 months, All Child: 0-18 years, Publication Date from 1995/10/01 to 2010/07/12

#22.

Search (#20 AND #13) NOT #5 Limits: Humans, Clinical Trial, Editorial, Practice Guideline, Randomized Controlled Trial, Case Reports, Comparative Study, Controlled Clinical Trial, Guideline, English, All Infant: birth-23 months, All Child: 0-18 years, Publication Date from 1995/10/01 to 2010/07/12

#21.

Search (#20 AND #13) NOT #5

#20.

Search ((“Arthritis, Juvenile Rheumatoid”[Mesh] OR “Lupus Erythematosus, Systemic”[Mesh]) OR “Scleroderma, Systemic”[Mesh]) OR “Crohn Disease”[Mesh]

#13.

Search “Immunosuppression”[Mesh] OR immunomodulation OR immunosuppressant OR immunosuppressive OR “immune modulation” OR “immune suppression”

#5.

Search “Bone Marrow Transplantation”[Mesh] OR (“Stem Cell Transplantation”[Mesh] OR “Peripheral Blood Stem Cell Transplantation”[Mesh] OR “Cord Blood Stem Cell Transplantation”[Mesh] OR “Hematopoietic Stem Cell Transplantation”[Mesh]) OR “bone marrow transplant*” OR “stem cell support” OR “stem cell transplant*”

Appendix Table D1. List of recently published studies (MS Word, 50K)

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