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Table 69Response to pharmacological treatment: findings of the network meta-analysis and of classical pair-wise comparisons versus placebo

DrugNetwork meta-analysis (results for 8 weeks)
Conditional response
Classical pair-wise meta-analysis – non-response
Pr of conditional response (95% CrI)Pr that drug is best in achieving response (in those who have not discontinued the drug due to side effects)HR versus placebo (95% CrI) – conditional responseRR versus placebo (95% CI) – non-response
Duloxetine0.651 (0.357, 0.919)0.3661.971 (1.549, 2.473)0.75 (0.62, 0.90)
Sertraline0.629 (0.329, 0.910)0.2771.859 (1.302, 2.591)0.70 (0.57, 0.86)
Venlafaxine XL0.616 (0.337, 0.892)0.1661.777 (1.482, 2.120)0.80 (0.71, 0.92)
Pregabalin0.590 (0.315, 0.872)0.0901.643 (1.349, 1.978)0.79 (0.73, 0.85)
Escitalopram0.579 (0.305, 0.870)0.0831.596 (1.237, 2.020)0.78 (0.63, 0.97)
Paroxetine0.519 (0.261, 0.822)0.0181.330 (1.059, 1.660)0.91 (0.73, 1.13)
Placebo0.428 (0.223, 0.684)0.000

From: 8, PHARMACOLOGICAL AND PHYSICAL INTERVENTIONS

Cover of Generalised Anxiety Disorder in Adults
Generalised Anxiety Disorder in Adults: Management in Primary, Secondary and Community Care.
NICE Clinical Guidelines, No. 113.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2011.
Copyright © 2011, The British Psychological Society & The Royal College of Psychiatrists.

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