Table 50Study information table for trials of venlafaxine comparing different doses

Venlafaxine 37.5 mg versus 75 mgVenlafaxine 75 mg versus 150 mgVenlafaxine 150 mg versus 225 mg
No. trials (participants)1 RCT
(n = 268)
4 RCTs
(N = 1027)
1 RCT
(N = 181)
Study IDALLGULANDER2001
RICKELS2000A
N/female% (see Appendix 15d for data for individual studies)275/65%1027/range 38–67%181/53%
Mean age (years) (see Appendix 15d for data for individual studies)454141
DiagnosisGAD by DSM-IV(1)–(4) GAD by DSM-IVGAD by DSM-IV
Baseline severity (HAM-A): mean (SD)HAM-A: Venlafaxine 37.5 mg 26.6 (range 20–44); 75 mg 26.3 (range 20–43)
  1. HRS-A: Venlafaxine 75 mg 26.3 (range 20–43); 150 mg 26.3 (range 17–38)
  2. Venlafaxine 75 mg 23.7 (4.1); 150 mg 23.0 (4.6)
  3. Venlafaxine 75 mg 27.9 (not reported); 150 mg 27.9 (not reported)
  4. Venlafaxine 75 mg 24.7 (4.4); 150 mg 24.5 (4.1)
Venlafaxine 150 mg 24.5 (4.1); 225 mg 23.6 (3.7)
Treatment length24 weeks(1) 24 weeks
(2)–(4) 8 weeks
8 weeks
Follow-upEnd of treatmentEnd of treatmentEnd of treatment

From: 8, PHARMACOLOGICAL AND PHYSICAL INTERVENTIONS

Cover of Generalised Anxiety Disorder in Adults
Generalised Anxiety Disorder in Adults: Management in Primary, Secondary and Community Care.
NICE Clinical Guidelines, No. 113.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2011.
Copyright © 2011, The British Psychological Society & The Royal College of Psychiatrists.

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