Table 46Study information table for trials comparing antidepressants with other pharmacological interventions

Venlafaxine versus pregabalinVenlafaxine versus buspironeVenlafaxine versus diazepamQuetiapine (50 mg and 150 mg) versus paroxetineQuetiapine (150 mg and 300 mg) versus escitalopram
No. trials (total participants)2 RCTs
(566)
1 RCT
(301)
1 RCT
(459)
1 RCT
(441)
1 RCT
(432)
Study ID
DAVIDSON1999HACKETT2003ASTRAZENECA2007AASTRAZENECA2007B
N/female % (see Appendix 15d for data for individual studies)566/Range 61–62%301/39%459/68%441/65%432/not reported
Mean age (years) (see Appendix 15d for data for individual studies)4338444138
Diagnosis(1)–(2) GAD by DSM-IVGAD by DSM-IVGAD by DSM-IVGAD by DSM-IVGAD by DSM-IV
Baseline severity (HAM-A): mean (SD)
  1. Venlafaxine 27.4 (SE = 0.4); pregabalin 27.6 (SE = 0.4)
  2. Venlafaxine 26.0 (4.6); pregabalin 26.3 (4.4)
Venlafaxine 23.6 (4.1); buspirone 23.8 (4.6)Venlafaxine 27.9 (not reported); diazepam 28.4 (not reported)Not reportedNot reported
Treatment length
  1. 8 weeks
  2. 6 weeks
8 weeks10 weeks8 weeks8 weeks
Follow-upEnd of treatmentEnd of treatmentEnd of treatmentEnd of treatmentEnd of treatment

From: 8, PHARMACOLOGICAL AND PHYSICAL INTERVENTIONS

Cover of Generalised Anxiety Disorder in Adults
Generalised Anxiety Disorder in Adults: Management in Primary, Secondary and Community Care.
NICE Clinical Guidelines, No. 113.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2011.
Copyright © 2011, The British Psychological Society & The Royal College of Psychiatrists.

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