Table 30Study information and evidence summary tables for trials of combined treatments

Buspirone and anxiety management training versus active control and anxiety management trainingBuspirone and non-directive therapy versus active control and non-directive therapy
No. trials
(total participants)
Study IDBOND2002B
N/% female60/45%
Mean age (years)34
DiagnosisGAD as a primary diagnosis by DSM-III-R
Baseline severity (clinician-rated)HAM-A score: 14.3–15.5HAM-A score: 14.4–16.3
Treatment length8 weeks
Follow-upNone reported
ResultsClinician-rated anxiety scores:
SMD = −0.33 (−1.16, 0.49)

Self-rated anxiety scores:
SMD = 0.06 (−0.76, 0.88)
Clinician-rated anxiety scores:
SMD = −0.18 (−1.09, 0.73)

Self-rated anxiety scores:
SMD = 0.07 (−0.84, 0.97)
CBT + IPT versus waitlist controlCBT versus CBT + IPT
No. trials
(participants in the subgroup)
Study IDREZVAN2008
N/% female36/100%
Mean age (years)20
DiagnosisDiagnosed with GAD as a primary diagnosis by DSM-IV
Treatment length8 weeks
Follow-up12 months
ResultsWorry score – PSWQ:
SMD = −2.89 (−4.10, −1.69) (post-treatment)
SMD = −3.52 (−4.87, −2.17) (12 months’ follow-up)

Quality of life – Oxford Happiness Scale:
SMD = −2.40 (−3.49, −1.31) (post-treatment)
SMD = −3.62 (−5.00, −2.25) (12 months’ follow-up)
Worry score – PSWQ:
SMD = −0.07 (CI, −0.87, 0.73) (post-treatment)
SMD = 0.79 (−0.05, 1.62) (12 months’ follow-up)

Quality of life – Oxford Happiness Scale:
SMD = −0.09 (−0.89, 0.71) (post-treatment)
SMD = 0.98 (0.13, 1.84) (12 months’ follow-up)


Cover of Generalised Anxiety Disorder in Adults
Generalised Anxiety Disorder in Adults: Management in Primary, Secondary and Community Care.
NICE Clinical Guidelines, No. 113.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2011.
Copyright © 2011, The British Psychological Society & The Royal College of Psychiatrists.

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