Table 86Input parameters utilised in the economic models of CCBT for the treatment of people with panic disorder

Input parameterDeterministic valueProbabilistic distributionSource of data - comments
Clinical data
END OF TREATMENT
Probability of non-panic-free statusBeta distribution
Model 1 – information control – 6 weeks0.964α = 27, β = 1Meta-analysis of KLEIN2006 and RICHARDS2006A
Model 2 – clinician-led CBT0.625α = 25, β = 15KIROPOULOS2008
Model 3 – waitlist0.961α = 49, β = 2Meta-analysis of CARLBRING2001 and CARLBRING2006
Model 4 – clinician-led CBT0.333α = 8, β = 16CARLBRING2005
Relative risk of non-panic-free status, CCBT versus comparatorLog-normal distribution
Model 1 – Panic Online versus information control – 6 weeks0.5095% CIs: 0.32 to 0.79Meta-analysis of KLEIN2006 and RICHARDS2006A
Model 2 – Panic Online versus clinician-led CBT1.0495% CIs: 0.76 to 1.44KIROPOULOS2008
Model 3 – Internet Psykiatri versus waitlist0.4495% CIs: 0.12 to 1.55Meta-analysis of CARLBRING2001 and CARLBRING2006
Model 4 – Internet Psykiatri versus clinician-led CBT0.6095% CIs: 0.23 to 1.58CARLBRING2005
1 YEAR’S FOLLOW-UP – selected data used in all 4 modelsBeta distribution
Probability of non-panic free status – clinician-led CBT0.125α = 3, β = 21All follow-up data from CARLBRING2005
Weekly post-treatment probability of non-panic-free status – clinician-led CBT0.026Determined by linked distributions
Probability of non-panic-free status – CCBT (Internet Psykiatri)0.080α = 2, β = 23
Weekly post-treatment probability of non-panic-free status – CCBT (Internet Psykiatri)0.024Determined by linked distributions
Log-normal distribution
Relative risk of non-panic-free status, CCBT versus clinician-led CBT0.6495% CIs: 0.12 to 3.50
Utility valuesBeta distributionAlonso et al., 2004a; data available in Kaltenthaler et al., 2006; distribution estimated from reported data using the method of moments
Panic-free status0.91α = 17,594, β = 1,740
Panic status0.76α = 141.36, β = 44.64
Cost dataGamma distribution
CCBT intervention cost - model 1£475α = 6.25, β = 75.94See Table 15 in Chapter 6; standard error of CCBT intervention cost assumed to be 40% of its mean estimate
– model 2£472α = 6.25, β = 75.44
– model 3£234α = 6.25, β = 37.44
– model 4£219α = 6.25, β = 35.04
Clinician-led CBT intervention cost - model 2£780α = 6.25, β = 124.80See Table 15 in Chapter 6; standard error of clinician-led CBT intervention cost assumed to be 40% of its mean estimate
– model 4£625α = 6.25, β = 100.00
Weekly health and social care cost£8α = 2.78, β = 2.92See Table 16 in Chapter 6; standard error of weekly health and social care cost assumed to be 60% of its mean estimate

From: 9, COMPUTERISED COGNITIVE BEHAVIOURAL THERAPY FOR PANIC DISORDER

Cover of Generalised Anxiety Disorder in Adults
Generalised Anxiety Disorder in Adults: Management in Primary, Secondary and Community Care.
NICE Clinical Guidelines, No. 113.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2011.
Copyright © 2011, The British Psychological Society & The Royal College of Psychiatrists.

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