Review questionWhat is the optimal screening programme to detect hypertension in multiple pregnancy in the antenatal period?

No.Bibliographic informationReason for exclusion
533AHRQ Research Activities
2002 (261) p18–18
In vitro fertilization doubles the risk of preeclampsia during pregnancy for women expecting more than one child
Short commentary with no original data
534American Journal of Obstetrics and Gynecology
1998 179 (4) p946–951
Predictors of pre-eclampsia in women at high risk. National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units
Caritis, S.
The relevant subgroup analysis did not report whether all included multifetal pregnancies were twins and triplets. Higher-order multiple pregnancies may have been included
535International Journal of Epidemiology
2007 36 (2) p412–419
Risk of early or severe pre-eclampsia related to pre-existing conditions
Catov, J. M.
Reports multiple pregnancies as a risk factor for pre-eclampsia. No subgroup analysis for risk factors of pre-eclampsia in twin or triplet pregnancies
536Database of Abstracts of Reviews of Effects
2010 (1)
Accuracy of fibronectin tests for the prediction of pre-eclampsia: a systematic review (Structured abstract)
Centre for Reviews and Dissemination.
Structured abstract – full paper ordered
537Paediatric and Perinatal Epidemiology
2001 15 (1) p40–46
Risk factors for pre-eclampsia/eclampsia among working women in Mexico City
Ceron-Mireles, P.
Only includes singletons
538BJOG: an International Journal of Obstetrics and Gynaecology
2010 117 (6) p695–700
Clinical and geographical variation in prophylactic and therapeutic treatments for pre-eclampsia in the UK
Chappell, L. C.
Not a prediction study
539Chung Hua i Hsueh Tsa Chih - Chinese Medical Journal
2000 63 (12) p869–875
Review of pre-eclampsia in Taiwan: a multi-institutional study
Chen, C. L
Not a prediction study
540Journal of the American Society of Nephrology
2002 13 (7) p1901–1906
Familial risk of preeclampsia in Newfoundland: a population- based study
Dawson, L. M.
Reports multiple pregnancies as a risk factor for pre-eclampsia. No subgroup analysis for risk factors of pre-eclampsia in twin or triplet pregnancies
541Obstetrics and Gynecology
2005 106 (5 Pt 1) p927–931
The effect of fetal number on the development of hypertensive conditions of pregnancy
Day, M. C.
Not a prediction study. Reports incidence of hypertensive disorders by fetal number
542American Journal of Obstetrics and Gynecology
1996 175 (3 Pt 1) p668–674
Very advanced maternal age: pregnancy after age 45
Dildy, G. A.
Only two twin pregnancies in study
543Italian Journal of Gynaecology and Obstetrics
1996 8 (2) p55–58
A laboratory study of the pre-eclampsia syndrome in Yaounde, Cameroon
Doh, A. S.
Unclear how many twins or triplets included. No subgroup analysis for twin or triplet pregnancies
544Journal of Maternal-Fetal and Neonatal Medicine
2006 19 (3) p141-Fetal
Preeclampsia in twin gestations: Association with IVF treatments, parity and maternal age
Erez, O.
Not a prediction study. Reports results of logistical regression analysis
545Journal of Obstetrics and Gynaecology Canada: JOGC
2008 30 (10) p918–949
Obstetrical complications associated with abnormal maternal serum markers analytes
Gagnon, A.
Not a prediction study. No subgroup analysis for twin or triplet pregnancies
546Obstetrics and Gynecology
1996 87 (3) p370–4.
Atypical presentation of preeclampsia in high-order multifetal gestations
Hardardottir, H.
Definition of pre-eclampsia does not meet the international standard
2000 36 (2) p149–158
Blood pressure patterns in normal pregnancy, gestational hypertension, and preeclampsia
Hermida, R. C.
Only includes singletons
548American Journal of Hypertension
2003 16 (3) p200–208
Differences in circadian blood pressure variability during gestation between healthy and complicated pregnancies
Hermida, R. C.
Only includes singletons
549Journal of the Society for Gynecologic Investigation
2003 10 (7) p418–422
Reduction of preeclampsia in multiple pregnancies by a dedicated monitoring protocol
Hirtenlehner, K.
Not a prediction study
550American Journal of Perinatology
1997 14 (10) p613–617
Maternal serum uric acid levels in pre-eclamptic women with multiple gestations
Hsu,C.D.; Chung,Y.K.; Lee,I.S.; Chou,K.; Copel,J.A.
Not a prediction study
551Fetal Diagnosis and Therapy
2000 15 (3) p160–164
Correlation of Doppler velocimetry findings in twin pregnancies including course of pregnancy and fetal outcome
Joern, H.
Data for IUGR and pre-eclampsia are presented together. Of the 52 cases in the study, 44 were IUGR and eight were pre-eclampsia, but it is not possible to extract data for the two conditions separately. As the majority of the cases were not pre-eclampsia, the findings are probably not relevant to the question
552BJOG: an International Journal of Obstetrics and Gynaecology
2009 116 (2) p268–276
Pulse wave analysis: A preliminary study of a novel technique for the prediction of pre-eclampsia
Khalil, A. A.
Only includes singletons
553European Journal of Obstetrics, Gynecology, and Reproductive Biology
2007 133 (1) p12–19
Accuracy of fibronectin tests for the prediction of pre-eclampsia: a systematic review. [48 refs]
Leeflang, M. M.
No subgroup analysis for twin or triplet pregnancies
554Obstetrics and Gynaecology
2010 115 (2) p365–375
Interpreting abnormal proteinuria in pregnancy
Lindheimer, M. D.
Review of methods for quantifying proteinuria in singleton pregnancies
555Archives of Gynecology and Obstetrics
1992 251 (2) p65–68
Is it worth weighing pregnant women in a developing country?
de, Muylder, X
Not a prediction study. No subgroup analysis for twin or triplet pregnancies
556Ultrasound in Obstetrics and Gynecology
2003 22 (2) p160–165
Cross-sectional and longitudinal evaluation of uterine artery Doppler velocimetry for the prediction of pre-eclampsia in normotensive women with specific risk factors
Parretti, E.
Only includes singletons
557Ultrasound in Obstetrics and Gynecology
2008 32 (2) p138–146
Uterine artery Doppler at 11 + 0 to 13 + 6 weeks and 21 + 0 to 24 + 6 weeks in the prediction of pre-eclampsia
Plasencia, W.
Only includes singletons
558Obstetrics and Gynecology
1993 82 (6) p978–83
Uterine artery Doppler velocity waveforms in twin pregnancies
Rizzo, G.
High prevalence of gestational hypertension and pre-eclampsia, half of the study population were taking antihypertensive medication at study entry. Not typical of the general population
559Archives of Gynecology and Obstetrics
2002 267 (2) p72–75
Maternal plasma adenosine and endothelin-1 levels in twin gestation complicated by preeclampsia
Shinagawa, T.
Test performed at a very late gestational age – not a prediction study
560Archives of Gynecology
1984 236 (1) p41–45
Serum levels of placenta-specific tissue protein 12 (PP12) in pregnancies complicated by pre-eclampsia, diabetes or twins
Than, G. N.
Looked at pregnancies with pre-eclampsia or twins, not both
561British Journal of Obstetrics and Gynaecology
1999 106 (6) p570–575
Twin mothers, pregnancy hypertension and pre-eclampsia
Thornton, J. G.
Unclear how many twins or triplets included. No subgroup analysis for twin or triplet pregnancies
562American Journal of Obstetrics and Gynecology
2001 184 (3) p374–381
An Australian twin study of the genetic basis of preeclampsia and eclampsia
Treloar, S. A.
Looks at the correlation of hypertension in adult twins who are pregnant. Unclear how many twins or triplet fetuses included in the pregnancies. No subgroup analysis for twin or triplet pregnancies
563Journal of Medical Sciences
2008 8 (8) p722–727
Serum B-hCG levels in a diagnosis and management of preeclampsia
Yousefnejad, K.
Only includes singletons
564Journal of Hypertension
vol 27 (10) p2044 to 2050 2009
Maternal EDN1 G5665T polymorphism influences circulating endothelin-1 levels and plays a role in determination of preeclampsia phenotype.
Aggarwal PK, Jain V, Srinivasan R et al.
Twin and triplet pregnancies were excluded
565Cochrane Database of Systematic Reviews
2010 (6)
Magnesium sulphate versus lytic cocktail for eclampsia
Duley, L.
Not a predictive study
566Hypertension in Pregnancy
29 p330–341 (2010)
Soluble endoglin for the prediction of preeclampsia in a high risk cohort
Maynard SE, Moore Simas TA, Bur L et al.
Not a prediction study – compared soluble endoglin levels in women with pre-eclampsia and those without
567Acta Clinica Belgica
vol 65 (2) p85 to 90 (2010)
Clinical and ultrasound work-up and follow-up of preeclampsia Richter J, van Miegham T and Devlieger R.
Narrative review
568Obstet Gynecol Clin N Am
37 (2010) p239–253
Abnormal placentation, angiogenic factors, and the pathogenesis of preeclampsia
Silasi M, Cohen B, Karumanchi SA et al.
Narrative review
569American Journal of Obstetrics and Gynecology
2010 203 (4) p381–384
Protein:creatinine ratio in uncomplicated twin pregnancy
Smith, N. A.
This study compares protein:creatinine ratio in uncomplicated twin pregnancies to that in uncomplicated singleton pregnancies. No data on predictive accuracy of protein:creatinine ratio for hypertension in multiple pregnancy

From: Appendix G, Excluded studies

Cover of Multiple Pregnancy
Multiple Pregnancy: The Management of Twin and Triplet Pregnancies in the Antenatal Period.
NICE Clinical Guidelines, No. 129.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2011 Sep.
Copyright © 2011, National Collaborating Centre for Women’s and Children’s Health.

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