Table 5.8Blood C-reactive protein – diagnostic statistics (children of all ages)

Study; evidence levelYears of data collection; proportion of Haemophilus influenzae type B (Hib); age rangeC-reactive protein threshold valueSensitivitySpecificityOR (95% CI) or PPV and NPVa
Gerdes, 199865[EL=III]1982–1996 (year of publication)

Hib: not reported

Age range: 1 day to 82 years
Findings from meta-analysis92%92%OR=150 (95% CI 44 to 509)
Dubos, 200862 [EL=III]1996–2005

Hib: n=7/96

Age range: 1 month to 15.9 years
≥20 mg/litre83%67%OR=9.9 (95% CI 4.8 to 20.8)
Dubos, 200663 [EL=III]1995–2004

Hib: n=1/21

Age range: 28 days to 16 years
≥20 mg/litre91%71%OR=24 (95% CI 5 to 155)
De Cauwer, 200735 EL=III]1997–2005

Hib: n=1/21

Age range: 0 to 15 years
≥20 mg/litre95%83%PPV=63%
NPV= 98%
Sormunen, 199966 EL=III]1977–1992

Hib: n=23/55b

Age range: 3 months to 15 years
>20 mg/litre96%93%PPV=83%
40 mg/litre86%100%PPV=100%

OR: odds ratio; NPV: negative predictive value; PPV: positive predictive value


All Gram-negative

OR: odds ratio; NPV: negative predictive value; PPV: positive predictive value

All Gram-negative

From: 5, Diagnosis in secondary care

Cover of Bacterial Meningitis and Meningococcal Septicaemia
Bacterial Meningitis and Meningococcal Septicaemia: Management of Bacterial Meningitis and Meningococcal Septicaemia in Children and Young People Younger than 16 Years in Primary and Secondary Care.
NICE Clinical Guidelines, No. 102.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2010.
Copyright © 2010, Royal College of Obstetricians and Gynaecologists.

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