Table 5.20Cerebrospinal fluid (CSF) glucose concentration - diagnostic statistics (children of all ages)a

Study; evidence levelYears of data collection; proportion of Haemophilus influenzae type B (Hib)Threshold valueSensitivitySpecificityPPVbNPVb
De Cauwer, 200735 [EL=III]1997–2005

1/22 Hib
CSF (glucose) 2.92 millimoles/litre
BM versus VM
57%87%57%87%
BenGershom, 198681 [EL=II]Not reported

Not reported
CSF (glucose) <2.2 millimole/litre
BM versus VM
47%96%89%71%
Sormunen, 199966 [EL=III]1977–1992

213/325 Hib
CSF (glucose) <2.0 millimole/litre
BM versus VM
31%100%100%79%
Sormunen, 199966 [EL=II]1977–1992

213/325 Hib
CSF (glucose) <2.5 millimole/litre
BM versus VM
35%96%79%79%
Corrall, 198180 [EL=II]1978–1980

12/24 Hib
CSF (glucose) <2.2 millimole/litre
BM versus VM/UM
78%100%100%86%
a

BM: bacterial meningitis; UM: undetermined meningitis; VM: viral meningitis

b

NPV: negative predictive value; PPV: positive predictive value

BM: bacterial meningitis; UM: undetermined meningitis; VM: viral meningitis

NPV: negative predictive value; PPV: positive predictive value

From: 5, Diagnosis in secondary care

Cover of Bacterial Meningitis and Meningococcal Septicaemia
Bacterial Meningitis and Meningococcal Septicaemia: Management of Bacterial Meningitis and Meningococcal Septicaemia in Children and Young People Younger than 16 Years in Primary and Secondary Care.
NICE Clinical Guidelines, No. 102.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2010.
Copyright © 2010, Royal College of Obstetricians and Gynaecologists.

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