Table 56Nitrous oxide + EMLA vs. EMLA; Ekbom 200558

Author(s): Ekbom 200558

Question: Should Nitrous oxide + EMLA vs. EMLA be used for intravenous cannulation?

Settings: Hospital

Quality assessmentSummary of findingsImportance
No of patientsEffectQuality
No of studiesDesignLimitationsInconsistencyIndirectnessImprecisionOther considerationsNitrous oxide + EMLAEMLARelative (95% CI)Absolute
Completion of procedure
1randomised trialvery serious1no serious inconsistencyno serious indirectnessserious2none25/25 (100%)21/21 (0%)RR 1.19 (0.99 to 1.43)0 more per 1,000VERY LOW
1

Randomisation and allocation concealment not well explained. Blinding not possible.

2

Small study with no power calculations.

Randomisation and allocation concealment not well explained. Blinding not possible.

Small study with no power calculations.

From: 6, Drugs for sedation in infants, children and young people

Cover of Sedation in Children and Young People
Sedation in Children and Young People: Sedation for Diagnostic and Therapeutic Procedures in Children and Young People [Internet].
NICE Clinical Guidelines, No. 112.
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