Table 12Oral midazolam + intravenous propofol vs. intravenous propofol; Paspatis 2006178

Question: Should oral midazolam plus intravenous propofol vs. intravenous propofol (with local anaesthesia in both arms) be used in children and young people under 19 years of age undergoing diagnostic and therapeutic procedures?

Settings: gastroenterology

Bibliography: Paspatis 2006178 (endoscopy)

Quality assessmentSummary of findingsImportance
No of patientsEffectQuality
No of studiesDesignLimitationsInconsistencyIndirectnessImprecisionOther considerationsoral midazolam plus intravenous propofolintravenous propofolRelative (95% CI)Absolute
Duration of procedure (Better indicated by less)
1randomised trialserious1no serious inconsistencyno serious indirectnessserious2none2628-MD 0.10 (-2.5 to 2.7)3LOW
Recovery from completion of procedure to recovery/discharge criteria met (measured with: REACT score; range of scores: 0-10; Better indicated by more)
1randomised trialserious1no serious inconsistencyno serious indirectnessno serious imprecisionnone2628-MD 18.20 (16.14 to 20.26)4MODERATE
1

Paspatis 2006178: ITT appeared to have been performed and no loss of follow up were reported; however, allocation concealment and blinding of patients were not stated and blinding of outcome assessors was not clear

2

Paspatis 2006178: wide confidence intervals

3

P=0.94

4

P<0.00001

Paspatis 2006178: ITT appeared to have been performed and no loss of follow up were reported; however, allocation concealment and blinding of patients were not stated and blinding of outcome assessors was not clear

Paspatis 2006178: wide confidence intervals

P=0.94

P<0.00001

From: 6, Drugs for sedation in infants, children and young people

Cover of Sedation in Children and Young People
Sedation in Children and Young People: Sedation for Diagnostic and Therapeutic Procedures in Children and Young People [Internet].
NICE Clinical Guidelines, No. 112.
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