Figure 40-4. Inflammatory response in experimental Legionella pneumonia. Alveolar macrophages are the only resident cells in the air spaces of the lungs.

Figure 40-4Inflammatory response in experimental Legionella pneumonia. Alveolar macrophages are the only resident cells in the air spaces of the lungs

Exponential bacterial growth begins soon after infection at a time when only macrophages are present; bacteria are most numerous 3 to 4 days later, but have virtually disappeared by the end of the first week. Infection elicits a large influx of polymorphonuclear leukocytes, followed by monocytes from the peripheral blood. Fluid exudation into the alveoli follows the pattern of the polymorphonuclear leukocytes. Specific immunologic responses (i.e., antibody and lymphocyte influx) are detectable 4 to 5 days after infection.

From: Chapter 40, Legionella

Cover of Medical Microbiology
Medical Microbiology. 4th edition.
Baron S, editor.
Copyright © 1996, The University of Texas Medical Branch at Galveston.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.