Figure 1.12. RNA is transcribed as a single strand which is complementary in base sequence to one strand (template strand) of a gene.

Figure 1.12RNA is transcribed as a single strand which is complementary in base sequence to one strand (template strand) of a gene

Various transcription factors (TF) are required to bind to a promoter sequence in the immediate vicinity of a gene Figure 1.12. RNA is transcribed as a single strand which is complementary in base sequence to one strand (template strand) of a gene., in order to subsequently position and guide the RNA polymerase that will transcribe the gene Figure 1.12. RNA is transcribed as a single strand which is complementary in base sequence to one strand (template strand) of a gene.. Chain synthesis is initiated with a nucleoside triphosphate and chain elongation occurs by successive addition of nucleoside monophosphate residues provided by rNTPs to the 3′ OH. This means that the 5′ end will have a triphosphate group, which may subsequently undergo modification (e.g. by capping; see Section 1.4.2) and the 3′ end will have a free hydroxyl group. Note that the sequence of the RNA will normally be identical to the sense strand of the gene (except U replaces T) and complementary to the template strand.

From: Chapter 1, DNA structure and gene expression

Cover of Human Molecular Genetics
Human Molecular Genetics. 2nd edition.
Strachan T, Read AP.
New York: Wiley-Liss; 1999.
Copyright © 1999, Garland Science.

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