Figure 2.21. Origins of translocations.

Figure 2.21Origins of translocations

Dicentric and acentric chromosomes are not stable through mitosis. Robertsonian translocations are produced by exchanges between the proximal short arms of the acrocentric chromosomes 13, 14, 15, 21 and 22. Both centromeres are present, but they function as one and the chromosome is stable. The small acentric fragment is lost, but this has no pathological consequences because it contains only repeated rDNA sequences, which are also present on the other acrocentric chromosomes.

From: Chapter 2, Chromosomes in cells

Cover of Human Molecular Genetics
Human Molecular Genetics. 2nd edition.
Strachan T, Read AP.
New York: Wiley-Liss; 1999.
Copyright © 1999, Garland Science.

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