Table VIEvaluation of the addictive potential of a psychoactive substance

Properties Observations
Induction of a physical dependencyIs there a withdrawal syndrome or not?
Induction of specific subjective effectsDiscrimination studies: does the animal recognise the subjective and specific effects of a drug or not?
Reinforcing propertiesDirect measurement Self-administration: does the animal self-administer the drug or not?
Indirect measurement Spatial conditioning (conditioned place preference): does the animal seek out or avoid the place where the substance was administered?
Self-stimulation: does the animal stimulate the cerebral structures belonging to the reward system or not?

From: Cannabis: Effects of consumption on health

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