Figure 4. The role of protein in remodelling RNA.

Figure 4

The role of protein in remodelling RNA. A) The structure of TadA (grey ribbon and surface) in complex with its substrate ASL (black ribbon and bonds). Superposed upon the substrate ASL is the corresponding segment of tRNAPhe (grey ribbon and bonds). The clashes between tRNAPhe and helix 5 of TadA illustrate the necessity of substrate remodelling. B) QueTGT (grey surface) in complex with its substrate ASL (black ribbon and bonds). As in TadA, superposition of tRNAPhe (grey ribbon) on the substrate ASL shows that the standard ASL conformation would lead to steric clashes with the protein. C) The β-hairpin of ArcTGT. The λ-form of tRNA (light grey ribbon and surface) is stabilised by a protein loop (black ribbon) containing the essential residues Lys465 and Thr466 (dark grey bonds). The loop is inserted into a region occupied by the bases U8, C25 and C48 in the canonical L-shaped tRNA.

From: Enzyme-RNA Substrate Recognition in RNA-Modifying Enzymes

Cover of Madame Curie Bioscience Database
Madame Curie Bioscience Database [Internet].
Austin (TX): Landes Bioscience; 2000-2013.
Copyright © 2000-2013, Landes Bioscience.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.