Table 5SAR of GPR55 Antagonist Probe ML191 (#3): CID23612552

Image ml193fu48.jpg
SBCCG MLS#PubChem SIDPubChem CIDPotency IC50 antagonists or EC50 agonists (μM) ± S.E.M.
RGPR55 Antagonist [n=3]*CB1 Agonist [n=2]CB1 Antagonist [n=4]*CB2 Agonist [n=2]CB2 Antagonist [n=2]*GPR35 Agonist [n=2]GRP35 Antagonists [n=2]
Image ml193fu49.jpg
MLS-035905887225751236125670.760 ± 0.133 [n=2]>329.62 ± 1.58 [n=2]>32>32>32>32
Image ml193fu50.jpg
MLS-036812687225750236125521.08 ± 0.10 [n=2]>3217.7 [n=1]>32>32>32>32
Image ml193fu51.jpg
MLS-036770599303152236125509.55 ± 2.62>327.11 [n=1]>32>32>32>32
Image ml193fu52.jpg
MLS-043715199303149236125432.70 ± 0.98>321.98 ± 0.90>3214.0 ± 1.0>32>32
Image ml193fu53.jpg
MLS-043714999303147236125417.62 ± 1.38 [n=2]>323.31 ± 0.58>3222.9 [n=1]>32>32
Image ml193fu54.jpg
MLS-0359128993031542361255417.4 ± 9.89 [n=2]>328.64 ± 1.39>32>32>32>32
Image ml193fu55.jpg
MLS-04371539930315123612548>32>3215.8 ± 1.9>32>32>32>32
Image ml193fu56.jpg
MLS-04371509930314823612542>32>3217.9 ± 3.4 [n=3]>32>32>32>32
Image ml193fu57.jpg
MLS-04371529930315023612544>32>3211.7 ± 1.5>32>32>32>32
Image ml193fu58.jpg
MLS-04371549930315323612553>32>32Avg 7.68 ± 0.78>32>32>32>32
*

replicates n=2,3 or 4 are as indicated for columns; the actual replicate number is noted in the cell where different than column default

From: Screening for Selective Ligands for GPR55 - Antagonists

Cover of Probe Reports from the NIH Molecular Libraries Program
Probe Reports from the NIH Molecular Libraries Program [Internet].

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