Figure 8 displays a forest plot of three studies (Bergeron 2000, Mano 1999, and Andersson 2005) reporting the difference in specificity between Hybrid Capture 2 (HC2) HPV testing and repeat cytology for the detection of CIN2+ among women referred with ASC-US cytology. Details of these studies are described in the section "Results: Key Question 3. What Are the Benefits of Using HPV Testing as a Screening Test, Either Alone or in Combination With Cytology, Compared to Not Testing for HPV?: Cytology testing with HPV triage of positive cytology (reflex HPV)" and the data from Figure 7 are presented in Appendix C, Table 3. The pooled difference in specificity between HC2 and repeat cytology showed no significant difference between HC2 and repeat cytology (p=0.65).

Figure 8Comparison of HC2 and Repeat Cytology Specificity for the Detection of CIN2+ Among Women Referred With ASC-US Cytology

ASC-US: atypical squamous cells of undetermined significance; CI: confidence interval; CIN: cervical intraepithelial neoplasia; HC2: Hybrid Capture 2

From: 3, Results

Cover of Screening for Cervical Cancer
Screening for Cervical Cancer: A Systematic Evidence Review for the U.S. Preventive Services Task Force [Internet].
Evidence Syntheses, No. 86.
Vesco KK, Whitlock EP, Eder M, et al.
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