Figure 4. Organization of representative genes encoding zebrafish L chains.

Figure 4

Organization of representative genes encoding zebrafish L chains. Some L chain type 1 clusters on chromosome 24 are represented on top line; the names of segments are some of those identified in reference 84; their updated linkage, polarity and distances were obtained from the Zv7 zebrafish genome assembly (www.ensembl.org) and reference 85. V (yellow boxes) and J (blue) gene segments are flanked by RSS (white triangle is RSS with 12 bp spacer, black triangle is RSS with 23 bp spacer) and C exons are depicted by black boxes. The transcriptional polarities are indicated by overhead arrows. A hypothetical series of rearrangements is depicted. Inversion recombination 1: rearrangement between J1c and V1i immediately upstream to form VJ (indicated as fused rectangles) and blunt-end joined RSS (fused triangles). Deletion recombination 2: The RSS-23 of the fused signal joint recombines with downstream V gene segment and deletes intervening DNA. Inversion recombination 3: the remaining J rearranges to upstream V, forming again VJ and blunt-end joined RSS. This VJ can be excised by deletion recombination 4 and replaced by rearrangement at another cluster, inversion recombination 5. A color version of this image is available at www.eurekah.com

From: V(D)J Recombination: Of Mice and Sharks

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