Table 2. Histologic Grade of Childhood Astrocytomas and Other Tumors of Glial Origin

TypeWHO Histologic Grade
Astrocytic Tumors:
Pilocytic astrocytomaI
Pilomyxoid astrocytomaaII
Pleomorphic xanthoastrocytoma II
Subependymal giant cell astrocytomaI
Diffuse astrocytoma:
Gemistocytic astrocytoma II
Protoplasmic astrocytomaII
Fibrillary astrocytomaII
Anaplastic astrocytoma III
GlioblastomaIV
Oligodendroglial Tumors:
OligodendrogliomaII
Anaplastic oligodendrogliomaIII
Mixed Gliomas:
OligoastrocytomaII
Anaplastic oligoastrocytomaIII

aIn 2007, the WHO further categorized astrocytomas, oligodendroglial tumors, and mixed gliomas according to histopathologic features and biologic behavior. It was determined that the pilomyxoid variant of pilocytic astrocytoma may be an aggressive variant that is more likely to disseminate, and it was reclassified as a grade II tumor.[1,2,5]

From: Childhood Astrocytomas Treatment (PDQ®)

Cover of PDQ Cancer Information Summaries
PDQ Cancer Information Summaries [Internet].
Bethesda (MD): National Cancer Institute (US); 2002-.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.