Figure 3. The domain structure of HIV-1 RT and telomerase reverse transcriptase (TERT).

Figure 3

The domain structure of HIV-1 RT and telomerase reverse transcriptase (TERT). The conserved reverse transcriptase (RT) motifs (named 1, 2, A, B', C, D, and E) are located in the N-terminal half of HIV-1 RT and are often referred to as the fingers and palm of a right hand. This conserved region is followed by a thumb domain and an RNase H domain in the HIV-1 polypeptide. In telomerase reverse transcriptase (TERT), the RT motifs positioned closer to the C-terminus and flanked by a long N-terminal extension and a short C-terminal extension. The N-terminal extension appears to contain four evolutionarily conserved motifs (GQ, CP, QFP, and T), all of which are required for telomerase function. A more detailed description is provided in the text.

From: Yeast Telomerases: Structure, Mechanisms and Regulation

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