Table 4. Prostate Cancer Susceptibility Loci Identified Through GWAS in Men of European Ancestry

SNPChromosomal LocusNearest Known Gene Within 100 kbRegionStudy CitationsORa
rs12185821p21KCNN3Intronic[186]1.06
rs42457391q32MDM4Exonic/Coding[186]0.91
rs101874242p11GGCXIntergenic[185]1.06–1.19
rs7210482p15EHBP1Intronic[189]1.15
rs14656182p21THADAIntronic[190]1.16–1.20
rs119022362p25GRHL1Intronic[186]1.07
rs12621278 2q31ITGA6Intronic[190]1.32–1.47
rs2292884 2q37MLPHIntronic[191]1.14
rs37715702q37FARP2Intronic[186]1.12
rs26607533p12VGLL3Intergenic[192]1.11–1.48
rs76116943q13SIDT1Intronic [186]0.91
rs109348533q21EEFSECIntronic[193]1.12
rs67639313q23ZBTB38Intronic[191]1.04–1.18
rs109366323q26CLDN11Intergenic[185]1.08–1.28
rs18942924q13AFMIntronic[186]0.91
rs125004264q22PDLIM5Intronic[190]1.14–1.17
rs17021918 Intronic[190]1.12–1.25
rs76796734q24TET2Intergenic[190]1.15–1.37
rs21218755p12FGF10Intronic[185]1.05–1.11
rs22426525p15TERTIntronic[191]1.15–1.39
rs68698415q35BOD1Intergenic[186]1.07
rs130067 6p21CCHCR1Exonic/Coding[191]1.05–1.20
rs3096702NOTCH4Intergenic[186]1.07
rs22736696q21ARMC2Intronic[186]1.07
rs19334886q25RSG17Intronic[186]0.89
rs9364554SLC22A3Intronic[192]1.17–1.26
rs104865677p15JAZF1Intronic[194,195]1.12–1.35
rs121551727p21NoneIntergenic[186]1.11
rs64656577q21LMTK2Intronic[192]1.03–1.19
rs29286798p21SLC25A37Intergenic[190]1.16–1.26
rs1512268NKX3-1Intergenic[190]1.13–1.28
rs11135910EBF2Intronic[186]1.11
rs100869088q24NoneIntergenic[87]1.14–1.25
rs7841060Intergenic[86]1.19
rs13254738Intergenic[75]1.11
rs16901979 Intergenic[74,195]1.31–1.66
rs16902094Intergenic[193]1.21
rs445114 Intergenic[193]1.14
rs620861Intergenic[86,87]1.11–1.28
rs6983267 Intergenic[73,75,87,194,195]1.13–1.42
rs7000448 Intergenic[75]1.14
rs1447295Intergenic[68,73,74,195]1.29–1.72
rs1099399410q11MSMBIntergenic[192,195]1.15–1.42
rs385069910q24TRIM8Intronic[186]0.91
rs496241610q26CTBP2Intronic[194]1.17–1.20
rs712790011p15THIntergenic[190]1.29–1.40
rs1122856511q13MYEOVIntergenic[193]1.23
rs7931342Intergenic[192]1.19–1.25
rs10896449Intergenic[195,196]1.09–1.20
rs12793759Intergenic[196]1.04–1.18
rs10896438Intergenic[196]1.02–1.12
rs1156881811q22MMP7Intergenic[186]0.91
rs90277412q13KRT8Intergenic[191]1.17
rs10875943TUBA1CIntergenic[185]1.02–1.18
rs127088412q24NoneIntergenic[186]1.07
rs800827014q22FERMT2Intronic[186]0.89
rs714152914q24RAD51BIntergenic[186]1.09
rs68423217p13VPS53Intergenic[186]1.10
rs1164974317q12HNF1BIntronic[195,197,198]0.86–1.28
rs4430796Intronic[102,195,197,198]0.87–1.12
rs7405696Intronic[198]1.11
rs4794758Intronic[198]0.88
rs1016990Intronic[198]1.07
rs3094509Intronic[198]1.06
rs1165049417q21ZNF652Intergenic[186]1.15
rs185996217q24NoneIntergenic[102,195]1.17–1.20
rs724199318q23SALL3Intergenic[186]0.92
rs810247619q13PPP1R14AIntergenic[193]1.12
rs2735839KLK3Intergenic[192]1.25–1.72
rs17632542KLK3Intergenic[199]0.62–0.76
rs242734520q13RBBP8NLIntergenic[186]0.94
rs6062509ZGPATIntronic[186]0.89
rs575916722q13BIKIntergenic[190]1.14–1.20
rs5945619Xp11NUDT11Intergenic[192,195]1.19–1.46
rs2405942Xp22SHROOM2Intronic[186]0.88
rs5919432Xq12ARIntergenic[191]1.06–1.14

GWAS = genome-wide association studies; OR = odds ratio; SNP = single nucleotide polymorphism.

aORs are reported as a range across the various stages of GWAS discovery and validation when available.

From: Genetics of Prostate Cancer (PDQ®)

Cover of PDQ Cancer Information Summaries
PDQ Cancer Information Summaries [Internet].
Bethesda (MD): National Cancer Institute (US); 2002-.

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