Table 4. International Neuroblastoma Risk Group Staging Systema

L1Localized tumor not involving vital structures as defined by the list of IDRFsa and confined to one body compartment.
L2Locoregional tumor with presence of one or more IDRFs.a
M Distant metastatic disease (except MS).
MSMetastatic disease in children younger than 18 months with metastases confined to skin, liver, and/or bone marrow.

IDRFs = image-defined risk factors.

aAdapted from Monclair et al.[23]; [2]

From: Neuroblastoma Treatment (PDQ®)

Cover of PDQ Cancer Information Summaries
PDQ Cancer Information Summaries [Internet].
Bethesda (MD): National Cancer Institute (US); 2002-.

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