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Chou R, McDonagh MS, Nakamoto E, et al. Analgesics for Osteoarthritis: An Update of the 2006 Comparative Effectiveness Review [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2011 Oct. (Comparative Effectiveness Reviews, No. 38.)

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Analgesics for Osteoarthritis: An Update of the 2006 Comparative Effectiveness Review [Internet].

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Appendix BCyclooxygenase Selectivity of NSAIDs

NSAID = nonsteroidal antiinflammatory drug

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Expressed as the ratio of the 50 percent inhibitory concentration of cycloogenase-2 to the 50 percent inhibitory concentration of cyclooxygenase-1 in whole blood. NSAIDs with a ratio of <1 indicate selectivity for cyclooxygenase-2.

Adapted from: Feldman M, McMahon AT. Do cyclooxygenase-2 inhibitors provide benefits similar to those of traditional nonsteroidal anti-inflammatory drugs, with less gastrointestinal toxicity? Annals of Internal Medicine 2000;132:134–43.

Expressed as the ratio of the 50 percent inhibitory concentration of cycloogenase-2 to the 50 percent inhibitory concentration of cyclooxygenase-1 in whole blood. NSAIDs with a ratio of <1 indicate selectivity for cyclooxygenase-2.

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