Table 2-3Example of dosing regimens for acute alcohol withdrawal

Treating alcohol withdrawal with chlordiazepoxide
Dosing RegimenDay 1Day 2Day 3Day 4
Fixed dose20 to 30 mg four times daily20 to 30 mg three times daily20 to 30 mg twice daily20 to 30 mg at bedtime
Symptom- triggered20 to 30 mg as needed up to hourly, based on symptoms*
Front- loaded^100 to 200 mg every 2 to 4 hours until sedation is achieved; then 50 to 100 mg every 4 to 6 hours as needed50 to 100 mg every 4 to 6 hours as needed50 to 100 mg every 4 to 6 hours as neededNone
*

These symptoms include pulse rate greater than 90 per minute, diastolic blood pressure greater than 90 mm Hg or signs of withdrawal.

^

Frequently, very little additional medication is necessary after initial loading.

These symptoms include pulse rate greater than 90 per minute, diastolic blood pressure greater than 90 mm Hg or signs of withdrawal.

Frequently, very little additional medication is necessary after initial loading.

From: 2, Acute Alcohol Withdrawal

Cover of Alcohol Use Disorders
Alcohol Use Disorders: Diagnosis and Clinical Management of Alcohol-Related Physical Complications [Internet].
NICE Clinical Guidelines, No. 100.
National Clinical Guideline Centre (UK).
Copyright © 2010, National Clinical Guidelines Centre.

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