Table 12Parameters used in the probabilistic sensitivity analysis

Description of variableMean valueProbability distributionParametersSource
SYMPTOM-TRIGGERED REGIMEN
Dose of drug (mg)
Daeppen (N=56)37.5
SD = 81.7
Gammaα = 0.211
β = 177.997
Mean and SD from Daeppen
Saitz (N=51)100
SD = 81.7
Gammaα = 1.498
β = 66.749
Mean from Saitz and SD from Daeppen
Lange-Asschenfeldt (N=33)4352
SD = 4589
Gammaα = 0.899
β = 4838.906
Mean and SD from Lange-Asschenfeldt
Weaver (N=91)28.8
SD = 81.7
Gammaα = 0.124
β = 231.687
Mean from Weaver and SD from Daeppen
Treatment duration (hour)
Daeppen (N=56)20
SD = 24.45
Gammaα = 0.669
β = 29.890
Mean and SD from Daeppen
Saitz (N=51)9
SD = 24.45
Gammaα = 0.135
β = 66.423
Mean from Saitz and SD from Daeppen
Lange-Asschenfeldt (N=33)100.8
SD = 69.6
Gammaα = 2.098
β = 48.057
Mean and SD from Lange-Asschenfeldt
Weaver (N=91)32
SD = 24.45
Gammaα = 1.713
β = 18.681
Mean from assumption (Section 6.3.2) and SD from Daeppen
Utility score (N=56)0.6614
SD = 0.07376
Betaα = 37.038
β = 18.962
Daeppen (Section 5)
Hourly cost of nurse time23
SE = 2.934
Gammaα = 61.46
β = 0.37
by assuming the 95% CI is equal to the mean ±25%
Unit Costs of Health and Social Care 2008
FIXED-DOSING REGIMEN
Dose of drug (mg)
 Daeppen (N=61)231.4
SD = 29.43
Gammaα = 61.822
β = 3.743
Mean and SD from Daeppen
 Saitz (N=50)425
SD = 29.43
Gammaα = 208.543
β = 2.038
Mean from Saitz and SD from Daeppen
 Lange-Asschenfeldt (N=32)9921
SD = 6599
Gammaα = 2.260
β = 4389.356
Mean and SD from Lange-Asschenfeldt
 Weaver (N=92)102.11
SD = 29.43
Gammaα = 12.038
β = 8.482
Mean from Weaver and SD from Daeppen
Treatment duration (hour)
 Daeppen (N=61)62.7
SD = 5.44
Gammaα = 132.843
β = 0.472
Mean and SD from Daeppen
 Saitz (N=50)68
SD = 5.44
Gammaα = 156.25
β = 0.435
Mean from Saitz and SD from Daeppen
 Lange-Asschenfeldt (N=32)180
SD = 79.2
Gammaα = 5.165
β = 34.848
Mean and SD from Lange-Asschenfeldt
 Weaver (N=92)96
SD = 5.44
Gammaα = 311.419
β = 0.308
Mean from assumption (Section 6.3.2) and SD from Daeppen
Utility score (N=60)0.642
SD = 0.07376
Betaα = 38.52
β = 21.48
Daeppen (Section 5)
Hourly cost of nurse time23
SE = 2.934
Gammaα = 61.46
β = 0.37
by assuming the 95% CI is equal to the mean ±25%
Unit Costs of Health and Social Care 2008

From: A.3, Health economic analysis – dosing regimens for acute alcohol withdrawal

Cover of Alcohol Use Disorders
Alcohol Use Disorders: Diagnosis and Clinical Management of Alcohol-Related Physical Complications [Internet].
NICE Clinical Guidelines, No. 100.
National Clinical Guideline Centre (UK).
Copyright © 2010, National Clinical Guidelines Centre.

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